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Merck
CN

G6416

Sigma-Aldrich

GW5074

powder

别名:

3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one

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About This Item

经验公式(希尔记法):
C15H8Br2INO2
分子量:
520.94
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

检测方案

≥98% (HPLC)

质量水平

形式

powder

储存条件

protect from light

颜色

yellow to orange-brown

溶解性

DMSO: 5 mg/mL, clear

储存温度

room temp

SMILES字符串

Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23

InChI

1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-

InChI key

LMXYVLFTZRPNRV-KMKOMSMNSA-N

基因信息

human ... RAF1(5894)

应用

GW5074 已用作 C2 小鼠骨骼肌成肌细胞、 HT-29 结直肠腺癌细胞系 和中性粒细胞中 cRaf1 的特异性抑制剂。

生化/生理作用

GW5074 是一种 cRaf1 激酶抑制剂, 位于丝裂原活化蛋白激酶 (MAPK)信号通路中 Ras的下游。它在 GW5074 中引起保护,防止亨廷顿氏舞蹈病′s的退化,且在治疗神经退行性疾病方面也具有治疗潜力。GW5074 与抗炎药物地塞米松联用,减轻侧流烟雾诱导的气道炎症。

其他说明

感光的

法律信息

根据葛兰素史克的协议出售,用于研究目的

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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