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Merck
CN

G6416

GW5074

powder

别名:

3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one

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关于此项目

经验公式(希尔记法):
C15H8Br2INO2
化学文摘社编号:
分子量:
520.94
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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产品名称

GW5074, powder

InChI key

LMXYVLFTZRPNRV-KMKOMSMNSA-N

SMILES string

Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23

InChI

1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

yellow to orange-brown

solubility

DMSO: 5 mg/mL, clear

storage temp.

room temp

Quality Level

Gene Information

human ... RAF1(5894)

Application

GW5074 已用作 C2 小鼠骨骼肌成肌细胞、 HT-29 结直肠腺癌细胞系 和中性粒细胞中 cRaf1 的特异性抑制剂。

Biochem/physiol Actions

GW5074 是一种 cRaf1 激酶抑制剂, 位于丝裂原活化蛋白激酶 (MAPK)信号通路中 Ras的下游。它在 GW5074 中引起保护,防止亨廷顿氏舞蹈病′s的退化,且在治疗神经退行性疾病方面也具有治疗潜力。GW5074 与抗炎药物地塞米松联用,减轻侧流烟雾诱导的气道炎症。

Legal Information

根据葛兰素史克的协议出售,用于研究目的

Other Notes

感光的

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Human intestinal epithelial cells respond to beta-glucans via Dectin-1 and Syk
Cohen-Kedar S, et al.
European Journal of Immunology, 44(12), 3729-3740 (2014)
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism
Chin PC, et al.
Journal of Neurochemistry, 90(3), 595-608 (2004)
Kaia Mobraten et al.
Lipids in health and disease, 12, 101-101 (2013-07-16)
Omega-3 PUFAs are known to have anti-inflammatory properties, and different mechanisms are involved. GPR120 is a G-protein coupled receptor that has recently received attention because of its anti-inflammatory signalling properties after binding omega-3 PUFAs. However, both omega-3 and omega-6 PUFAs
ERK12 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts
Kefaloyianni E, et al.
Cellular Signalling, 18(12), 2238-2251 (2006)
Raf-1 interferes with Ras and Rap1A effector functions in yeast.
Ruggieri R, et al.
Molecular Biology of the Cell, 5(2), 173-181 (1994)

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