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Merck
CN
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文件

安全信息

A8301

Sigma-Aldrich

糖化白蛋白 人

lyophilized powder

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About This Item

CAS号:
70024-90-7
MDL编号:
MFCD00130433
UNSPSC代码:
12352202
NACRES:
NA.25

生物来源

human

质量水平

200

检测方案

90-100% protein basis (biuret)

形式

lyophilized powder

标记范围

1-5 mol hexose (as fructosamine) per mol albumin

技术

cell culture | mammalian: suitable

UniProt登记号

P02768

储存温度

−20°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

基因信息

human ... ALB(213)

相关类别

一般描述

白蛋白基因定位于人染色体 4q13.3。在肝脏中，它合成时是具有 609 个氨基酸的白蛋白前体。通过信号肽的切割产生具有 585 个残基的成熟白蛋白。白蛋白是血清中主要的循环蛋白。它包含三个结构域（I、II 和 III），每个结构域又细分为两个亚结构域 A 和 B。与白蛋白相关配体结合位点总共有 6 个。结构域 IIA 和 IIIA 带有小的杂环或芳香族化合物结合位点。长链脂肪酸结合位点位于 IB 和 IIIB 结构域中。

应用

糖化人白蛋白已用于：
  • 作为用于视网膜小胶质细胞活化的无血清培养基的成分
  • 刺激永生化的近端小管上皮细胞（HK-2）产生纤连蛋白
  • 作为人视网膜微血管内皮细胞（HRMEC）培养物的培养基补充剂，以测试其对序列相似家族 18 成员 B（FAM18B）表达的影响


天然存在的糖化白蛋白是糖尿病患者血糖控制的敏感指标。

生化/生理作用

白蛋白对于生理过程至关重要，并且是脂质、金属离子和氨基酸的主要转运蛋白。它具有抗氧化功能，并能与药物结合。白蛋白基因的突变与常染色体隐性遗传病（称为白蛋白血症）有关，其特征是白蛋白水平较低。白蛋白主要糖基化位点是赖氨酸 525。糖化白蛋白是糖尿病患者血糖的标志物，可用于评估基于 HbA1c 的血糖控制。

外形

含有柠檬酸盐缓冲液盐的冻干粉

制备说明

糖化体外

其他说明

查看更多关于 人血清白蛋白的信息。

免责声明

仅供研究使用。在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the carbohydrate used for the glycation step of Product A8301, Albumin, glycated human?

    The starting carbohydrate for the albumin modification is glucose.

  4. How much is Product A8301, Albumin, glycated human, glycated?

    The degree of glycation varies with each individual lot.  This value can be found on the Certificate of Analysis for each lot. 

  5. What is the molecular weight of Product A8301, Albumin, glycated human?

    Because the degree of glycation varies with each lot, the calculated molecular weight (MW) varies with each lot.  The parent albumin has a molecular weight of approximately 66,478 Daltons. Each hexose unit adds approximately 180 Daltons to the molecular weight.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Glycated albumin is a better glycemic indicator than glycated hemoglobin values in hemodialysis patients with diabetes: effect of anemia and erythropoietin injection
Inaba M, et al.
Journal of the American Society of Nephrology, 18(3), 896-903 (2007)
A novel mutation in the albumin gene (c. 1A> C) resulting in analbuminemia
Caridi G, et al.
European Journal of Clinical Investigation, 43(1), 72-78 (2013)
Role of FAM18B in diabetic retinopathy
Wang AL, et al.
Molecular Vision, 20(1), 1146-1146 (2014)
Stephanie D Burr et al.
Cells, 10(3) (2021-04-04)
Cardiovascular disease, specifically heart failure, is a common complication for individuals with type 2 diabetes mellitus. Heart failure can arise with stiffening of the left ventricle, which can be caused by "active" cardiac fibroblasts (i.e., myofibroblasts) remodeling the extracellular matrix
Glycated albumin: a potential biomarker in diabetes
Freitas P, et al.
Archives of endocrinology and metabolism, 61(3), 296-304 (2017)
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