跳转至内容
Merck
CN
所有图片(7)

文件

安全信息

A9511

Sigma-Aldrich

白蛋白 来源于人类血清

lyophilized powder, ≥97% (agarose gel electrophoresis)

别名:

HSA

登录查看公司和协议定价
所有图片(7)

About This Item

CAS号:
70024-90-7
EC 号:
274-272-6
MDL编号:
MFCD00081418
UNSPSC代码:
12352202
eCl@ss:
42010201
NACRES:
NA.25

生物来源

human

质量水平

300

检测方案

≥97% (agarose gel electrophoresis)

形式

lyophilized powder

分子量

monomer calculated mol wt 66478 Da

技术

ELISA: suitable
tissue culture: suitable
western blot: suitable

杂质

HIV I and HIVII, HCV and HBsAg, tested negative

溶解性

H2O: soluble 50 mg/mL

UniProt登记号

P02768

储存温度

2-8°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

基因信息

human ... ALB(213)

正在寻找类似产品? 访问 产品对比指南

相关类别

一般描述

人白蛋白的分子量为67 kDa。
白蛋白是血浆中最丰富的蛋白质。肝脏可产生人白蛋白。

应用

与白蛋白结合的荧光已被用于慢性肾衰竭患者的血清中。
来源于人血清的白蛋白已被用于：
  • 标准化分子排阻色谱柱
  • 制备烟草花叶病毒（TMV）-聚乙二醇（PEG8）-血清白蛋白（SA）颗粒
  • 在Fenton系统中分析其氧化后修饰

生化/生理作用

白蛋白转换可见于患有缺铁性贫血的婴儿。血清白蛋白是肝病的可靠预后指标。在晚期肝病中可见白蛋白的氧化修饰。
血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白，对调节血液的胶体渗透压至关重要。研究还发现白蛋白可结合外源物质，特别是药物（例如布洛芬、华法林），并强烈影响其药代动力学。导致白蛋白氧化还原状态变化的氧化应激对其生理功能具有广泛的影响。

制备说明

使用Cohn, E.J., et al., J. Am. Chem. Soc., 69, 1753 (1947)中报道的方法IV进行制备。

其他说明

更多信息参见人血清白蛋白。

免责声明

仅供研究使用。在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves

法规信息

常规特殊物品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Can Product A9511, Human serum albumin (HSA), be used for cell culture applications?

    Although A9511 is not sterile or endotoxin tested, it can probably still be used in cell culture. Filtering a solution of HSA through a 0.45 micron filter, then a 0.2 micron filter would provide a solution that is sterile, and likely suitable for cells. A5843 is an HSA product that has been endotoxin tested.

  6. What are the impurities for Product A9511, Human serum albumin (HSA)?

    The impurities present are alpha-globulin and beta-globulin.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

H A Schwertner et al.
Clinical chemistry, 26(5), 649-652 (1980-04-01)
A band that is strongly fluorescent and migrates electrophoretically with serum albumin is commonly found in electrophoretograms of sera from patients with chronic renal failure. We sought to determine whether the fluorescence originates from binding of certain still-unidentified metabolites or
Daniele Sanna et al.
Journal of inorganic biochemistry, 103(4), 648-655 (2009-02-10)
The complexation of VO(2+) ion with the high molecular mass components of the blood serum, human serum transferrin (hTf) and albumin (HSA), has been re-examined using EPR spectroscopy. In the case of transferrin, the results confirm those previously obtained, showing
Effects of Fenton Reaction on Human Serum Albumin: An In Vitro Study
Khosravifarsani M, et al.
Electron Physician, 8(9), 2970-2970 (2016)
Serum albumin camouflage of plant virus based nanoparticles prevents their antibody recognition and enhances pharmacokinetics
Pitek A, et al.
Biomaterials, 89(7-8), 89-97 (2016)
Elham Behzadi et al.
International journal of nanomedicine, 14, 257-270 (2019-01-16)
Recently, nanomaterials have moved into biological and medicinal implementations like cancer therapy. Therefore, before clinical trials, their binding to plasma proteins like human serum albumin (HSA) and their cytotoxic effects against normal and cancer cell lines should be addressed. Herein
查看所有相关文献

商品

Albumin in Cell Culture

Explore serum albumin's role in serum-free cell culture systems for biomanufacturing.

白蛋白在细胞培养中的应用

本页将全面阐述血清白蛋白和其他重要细胞培养成分如何影响用于单克隆抗体等外源蛋白生物制造的无血清细胞培养系统的性能，并介绍白蛋白的体外化学和生物化学过程。本页面将介绍白蛋白在体外化学和生物化学领域的应用。这些深度知识可能也适用于离体和组织工程学应用。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门