所有图片(2)
About This Item
经验公式（希尔记法）:
C16H18N3NaO4S
CAS号:
分子量:
371.39
Beilstein:
4119211
MDL编号:
UNSPSC代码:
51280000
NACRES:
NA.76
价格与库存信息目前不能提供
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生物来源
microbial
质量水平
无菌性
0.2 μm filtered
表单
liquid
自燃温度
301 °C
储存条件
(Tightly closed. Keep locked up or in an area accessible only to qualified or authorized )
浓度
100 mg/mL
颜色
colorless to light yellow
mp
215 °C (dec.) (lit.)
溶解性
DMSO: 100 mg/mL
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一般描述
化学结构:β-内酰胺
氨苄西林， 一种超广谱β-内酰胺家族的成员，是青霉素的半合成衍生物，广泛用作多功能广谱抗生素。其作用机理是通过结合青霉素结合蛋白(PBP)，抑制细菌细胞壁合成，破坏细菌细胞壁形成必不可少的肽聚糖合成过程。这种抗生素可有效抑制多种细菌，包括革兰氏阳性菌和革兰氏阴性菌，如大肠杆菌、β-内酰胺敏感型耐万古霉素肠球菌 (VRE)、金黄色葡萄球菌和肺炎链球菌。在科学研究，特别是在微生物学、生物化学和细胞生物学研究中，氨苄西林起关键作用。其实验室应用涵盖了抗生素耐药性和渗透限制的研究，多种抗生素之间协同相互作用的研究，并可作为选择和维持培养大肠杆菌中重组质粒的关键成分。一种方便即用的100 mg/mL 氨苄西林DMSO溶液，可用于选择具有特定抗性的细菌细胞。
应用
生化/生理作用
作用方式：该ß-内酰胺抗生素通过灭活位于细菌的细胞膜内表面的转肽酶从而抑制细菌细胞壁合成。
耐药性机制：ß-内酰胺酶切开氨苄青霉素的ß-内酰胺环,使其失去活性。
抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。
耐药性机制：ß-内酰胺酶切开氨苄青霉素的ß-内酰胺环,使其失去活性。
抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。
作用机制：该ß-内酰胺抗生素通过灭活细菌细胞膜内表面的转肽酶，从而抑制细菌细胞壁合成。耐药模式ß-内酰胺酶切开氨苄青霉素的ß-内酰胺环,使其失去活性。
抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。
抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。
特点和优势
- 高品质抗生素，适合各种研究用途
- 适于细胞生物学和生物化学研究。
相关产品
产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kenneth H Rand et al.
The Journal of antimicrobial chemotherapy, 53(3), 530-532 (2004-02-14)
We used a novel screening method to look for synergy between daptomycin and 18 other antibiotics against 19 strains of high-level vancomycin-resistant enterococci (VRE) (vancomycin MIC > or = 256 mg/L). In this approach, daptomycin was incorporated into Ca(2+)-supplemented Mueller-Hinton
J N Anderl et al.
Antimicrobial agents and chemotherapy, 44(7), 1818-1824 (2000-06-20)
The penetration of two antibiotics, ampicillin and ciprofloxacin, through biofilms developed in an in vitro model system was investigated. The susceptibilities of biofilms and corresponding freely suspended bacteria to killing by the antibiotics were also measured. Biofilms of Klebsiella pneumoniae
Maria Chiara Lionetti et al.
Journal of clinical medicine, 9(8) (2020-08-14)
Melanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits behind its metastatic capabilities. The detailed molecular mechanisms controlling melanoma plasticity are still not completely understood. Here we combine
Indrikis A Krams et al.
The Journal of experimental biology, 220(Pt 22), 4204-4212 (2017-09-25)
Communities of symbiotic microorganisms that colonize the gastrointestinal tract play an important role in food digestion and protection against opportunistic microbes. Diet diversity increases the number of symbionts in the intestines, a benefit that is considered to impose no cost
Carlos Pinzon-Arteaga et al.
Scientific reports, 10(1), 7411-7411 (2020-05-06)
Phenotypic selection during animal domestication has resulted in unwanted incorporation of deleterious mutations. In horses, the autosomal recessive condition known as Glycogen Branching Enzyme Deficiency (GBED) is the result of one of these deleterious mutations (102C > A), in the first exon
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