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安全信息

A9518

Sigma-Aldrich

氨苄西林 钠盐

别名:

氨苄青霉素 钠盐

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About This Item

经验公式（希尔记法）:
C16H18N3NaO4S
CAS号:
69-52-3
分子量:
371.39
Beilstein:
4119211
EC 号:
200-708-1
MDL编号:
MFCD00064313
UNSPSC代码:
12352107
PubChem化学物质编号:
24891463
NACRES:
NA.76

生物来源

synthetic (chemical)

质量水平

200

形式

powder

颜色

white to off-white

mp

215 °C (dec.) (lit.)

溶解性

water: 50 g/L

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

应用

agriculture

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

SMILES字符串

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

InChI key

KLOHDWPABZXLGI-YWUHCJSESA-M

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相关类别

一般描述

氨苄西林钠盐是超广谱β-内酰胺家族成员，是青霉素的半合成衍生物，具有广谱抗生素的作用。该β-内酰胺抗生素通过与青霉素结合蛋白(PBP)结合抑制细胞壁关键组分肽聚糖的合成，从而抑制细胞壁合成。氨苄西林钠盐具有抗多种革兰氏阳性菌和革兰氏阴性菌活性，包括大肠杆菌(E. coli)、β-内酰胺敏感VRE、耐万古霉素肠球菌(VRE)、金黄色葡萄球菌(Staphylococcus aureus)和肺炎链球菌(Streptococcus pneumoniae)。常被研究型实验室用于研究抗生素的耐药性和渗透性限制、多种抗生素之间的协同作用、大肠杆菌重组质粒的筛选和维持。

应用

氨苄西林钠盐已用于：
  • 突变和转化细胞的氨苄西林抗性筛选

生化/生理作用

作用方式：该ß-内酰胺抗生素通过灭活位于细菌的细胞膜内表面的转肽酶从而抑制细菌细胞壁合成。

耐药性机制：ß-内酰胺酶切开氨苄青霉素的ß-内酰胺环,使其失去活性。

抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。

特点和优势

  • 高品质抗生素，适合各种研究用途
  • 适于细胞生物学和生物化学研究。

注意

据报道，该产品在25°C、43%和81%相对湿度下可稳定6周。 另外的研究表明氨苄青霉素在溶液中的稳定性与pH、温度和缓冲液的性质有关。 当储存在pH值7以上时，它的活性很快就会丧失。 推荐最佳保存条件为2-8℃，pH 3.8-5，一周内其活性可保留90%。

制备说明

据报道，氨苄青霉素微溶于水，几乎不溶于酒精、氯仿、醚和固定油脂，但溶于稀酸或稀碱。 该溶液不应高压灭菌;原液应通过过滤消毒并冷冻保存，可稳定数月。

储存及稳定性

Tightly closed. Dry. Keep locked up or in an area accessible only to qualified or authorized

其他说明

如需了解生化试剂系列的更多信息，请填写此表。
将容器密封在干燥、通风良好的地方。储存类别(TRGS 510): 不可燃的固体

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象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H317,H334

危险分类

Resp. Sens. 1A - Skin Sens. 1A

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. What is the solubility of Product A9518, Ampicillin sodium salt?

    This product is soluble in water at a concentration of 50 mg/mL, producing a clear, colorless to faint yellow solution.  

  3. Is Ampicillin product stable in solution?

    We recommend using freshly prepared solutions. A concentrated solution of sodium ampicillin in water (approximately 330 mg/mL) may be expected to lose about 10% potency in 20 hours at -20°C.

  4. How do I use Ampicllin in agar plates?

    For plates, add ampicillin to autoclaved media cooled to 48°C, to a final concentration of 35-50 μg/mL. Pour the plates, and allow them to cool completely. Plates may be stored at 2-8°C for up to only 1-2 weeks before use.

  5. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Antibiotic combination therapies are important for the efficient treatment of many types of infections, including those caused by antibiotic-resistant pathogens. Combination treatment strategies are typically used under the assumption that synergies are conserved across species and strains, even though recent
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