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Merck
CN

PHR2838

氨苄西林

pharmaceutical secondary standard, certified reference material

别名:

D-(−)-α-氨苄青霉素

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关于此项目

经验公式（希尔记法）:
C16H19N3O4S
化学文摘社编号:
69-53-4
分子量:
349.40
NACRES:
NA.24
UNSPSC Code:
41116107
Beilstein/REAXYS Number:
1090925
MDL number:
MFCD00005175

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产品名称

氨苄西林, pharmaceutical secondary standard, certified reference material

SMILES string

[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c3ccccc3)C(O)=O

InChI key

AVKUERGKIZMTKX-NJBDSQKTSA-N

InChI

1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. A1000000
traceable to USP 1033000

description

Pharmaceutical Secondary Standard; Certified Reference Material

API family

ampicillin

form

solid

packaging

pkg of 500 mg

mp

208 °C (dec.) (lit.)

application(s)

pharmaceutical small molecule

storage temp.

2-8°C

Quality Level

300

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相关类别

Biochem/physiol Actions

作用机制：氨苄西林是一种半合成的青霉素和ß-内酰胺抗生素，其通过灭活位于细菌的细胞膜内表面的转肽酶从而抑制细菌细胞壁合成。

耐药性机制：ß-内酰胺酶切开氨苄青霉素的ß-内酰胺环,使其失去活性。

抗菌谱：对革兰氏阳性菌（类似于苄青霉素）和革兰氏阴性菌（类似于四环素和氯霉素）均有效。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Ampicillin may be used as a pharmaceutical reference standard in the determination of the analyte in human plasma, urine, pharmaceutical formulations and bovine milk by spectrophotometric and chromatographic techniques.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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