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安全信息

K0254

Sigma-Aldrich

Kanamycin solution from Streptomyces kanamyceticus

liquid, suitable for cell culture and plant cell culture, BioReagent

别名:

Kanamycin A

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About This Item

CAS号:
25389-94-0
MDL编号:
MFCD00070289
UNSPSC代码:
12352207
PubChem化学物质编号:
329817120
NACRES:
NA.76

product name

Kanamycin solution from Streptomyces kanamyceticus, 50 - 60 mg/mL in 0.9% NaCl, BioReagent, liquid, 0.1 μm filtered, suitable for cell culture

生物来源

Streptomyces kanamyceticus

质量水平

200

无菌性

0.1 μm filtered

产品线

BioReagent

形式

liquid

浓度

50 - 60 mg/mL in 0.9% NaCl

技术

cell culture | mammalian: suitable
cell culture | plant: suitable

杂质

endotoxin, tested

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1

InChI key

SBUJHOSQTJFQJX-NOAMYHISSA-N

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相关类别

一般描述

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 2 mL/L.

应用

Kanamycin solution from Streptomyces kanamyceticus has been used:
  • to induce deafness in neonatal rats
  • as an endothelial growth medium component for culturing human umbilical vein endothelial cells (HUVECs)
  • as medium component for Mycobacteria Cultures and Top10 E coli cells

生化/生理作用

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.

Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.

Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

注意

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360D

预防措施声明

P201 - P308 + P313

危险分类

Repr. 1B

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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