跳转至内容
Merck
CN

C2105

Sigma-Aldrich

Z-Val-Ala-Asp氟甲基酮

powder, ≥90% (TLC)

别名:

Z-VAD-FMK,未甲基化

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C21H28FN3O7
分子量:
453.46
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥90% (TLC)

形式

powder

运输

dry ice

储存温度

−20°C

SMILES字符串

CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CF

InChI

1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1

InChI key

SUUHZYLYARUNIA-YEWWUXTCSA-N

Amino Acid Sequence

Z-Val-Ala-Asp-OMe-FMK

生化/生理作用

非甲基化竞争性和不可逆抑制剂 caspase-1 以及其他 caspase可直接与纯化的酶一起使用。它不需要酯酶即可水解 O-甲酯,就像细胞可渗透的形式 Z-Val-Ala-Asp(OMe)氟甲基酮(货号 V-116)一样。

特点和优势

该化合物在受体分类和信号转导手册的 半胱天冬酶 页面上有详细描述。如需浏览其他手册页面,请点击此处

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Longlong Xie et al.
Signal transduction and targeted therapy, 5(1), 56-56 (2020-05-21)
Latent membrane protein 1 (LMP1) is a major Epstein-Barr virus (EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell survival. Recently, mitochondrial fission has been demonstrated as a crucial mechanism in oncovirus-mediated carcinogenesis. Mitochondrial dynamin-related protein
Xintong Jiang et al.
JACC. Basic to translational science, 4(3), 304-317 (2019-07-18)
CANTOS (Canakinumab Antiinflammatory Thrombosis Outcome Study) confirmed interleukin (IL)-1β as an appealing therapeutic target for human atherosclerosis and related complications. However, there are serious gaps in our understanding of IL-1 production in atherosclerosis. Herein the authors show that complex plaques
Tonghui Li et al.
Frontiers in pharmacology, 13, 854526-854526 (2022-06-07)
Aloe-emodin (1,8-dihydroxy-3-hydroxymethyl-anthraquinone), derived from some Chinese edible medicinal herbs, exerts a potential anticancer activity on various cancer cells, making it a drug candidate for cancer therapy. Yet, the role of aloe-emodin in pyroptosis, a new type of cell death, is
Teruyuki Kajiume et al.
Cell death discovery, 4, 111-111 (2018-12-12)
Mature neutrophils must be quickly removed from inflammatory sites to prevent tissue damage. Neutrophil removal is thought to be accomplished primarily through caspase-dependent apoptosis, which involves several genes of mitochondrial origin. However, mature neutrophils show reduced gene transcription and mitochondrial
Feng Shi et al.
Theranostics, 9(9), 2424-2438 (2019-05-28)
EBV infection is a recognized epigenetic driver of carcinogenesis. We previously showed that EBV could protect cancer cells from TNF-induced necroptosis. This study aims to explore the epigenetic mechanisms allowing cancer cells with EBV infection to escape from RIP3-dependent necroptosis.

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门