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Merck
CN

78246

Supelco

姜黄素

matrix substance for MALDI-MS, ≥99.5% (HPLC)

别名:

(E,E)-1,7-双(4-羟基-3-甲氧基苯基)-1,6-庚二烯-3,5-二酮, 二阿魏酸甲烷, 天然黄3

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About This Item

线性分子式:
[HOC6H3(OCH3)CH=CHCO]2CH2
CAS号:
分子量:
368.38
颜色索引号:
75300
Beilstein:
2306965
EC 号:
MDL编号:
UNSPSC代码:
12000000
PubChem化学物质编号:
NACRES:
NA.21

等级

matrix substance for MALDI-MS

质量水平

蒸汽密度

13 (vs air)

方案

≥99.5% (HPLC)

表单

powder

技术

MALDI-MS: suitable

mp

183-188 °C

痕量阳离子

Na: ≤50 mg/kg

储存温度

2-8°C

SMILES字符串

COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O

InChI

1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChI key

VFLDPWHFBUODDF-FCXRPNKRSA-N

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应用


  • Hybrid Ethylcellulose Polymeric Films: Ag(I)-Based Components and Curcumin as Reinforcing Ingredients for Enhanced Food Packaging Properties:本文开发一种掺入姜黄素的杂化乙基纤维素膜来改进食品包装,说明本品在组分相容性和性能评估方面的分析化学应用(Crispini A et al., 2024)。

  • Intelligent double-layer film based on gellan gum/modified anthocyanin/curcumin/sodium alginate/zinc oxide for monitoring shrimp freshness:本文制造一种含有姜黄素的智能膜用于实时监测虾新鲜度,体现姜黄素在食品安全和保质期延长中的实用性(Li C et al., 2024)。

  • Cyclodextrin-grafted redox-responsive hydrogel mediated by disulfide bridges for regulated drug delivery:本文研究一种含姜黄素的环糊精水凝胶,说明姜黄素开发先进给药系统的作用,体现靶向治疗应用潜力(Xu X et al., 2024)。

生化/生理作用

一种天然酚类化合物。它是有效的抗肿瘤剂,具有抗炎和抗氧化活性。除了具有化疗活性外,姜黄素还被认为是潜在的化学预防剂。它能够诱导癌细胞凋亡并抑制佛波酯诱导的蛋白激酶C(PKC)活性。据报道,它能抑制外周血单核细胞和肺泡巨噬细胞产生炎性细胞因子。它是EGFR酪氨酸激酶和IκB激酶的有效抑制剂。它能抑制诱导型一氧化氮合酶(iNOS)、环加氧酶和脂氧合酶。它易于渗透到细胞质中,在质膜、内质网和核膜等膜结构中积累。
它是一种天然酚类化合物,是姜黄的黄色来源。它是有效的抗肿瘤剂,作用于高度多样化的肿瘤特异性通路。它具有抗炎和抗氧化活性。它能够诱导癌细胞凋亡并抑制佛波酯诱导的蛋白激酶C(PKC)活性。据报道,它能抑制外周血单核细胞和肺泡巨噬细胞产生炎性细胞因子。它是EGFR酪氨酸激酶和IκB激酶的有效抑制剂。它能抑制诱导型一氧化氮合酶(iNOS)、环加氧酶(COX-2)和5-脂氧合酶(5-LOX)。

相关产品

产品编号
说明
价格

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

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Lot/Batch Number

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Michal Heger et al.
Pharmacological reviews, 66(1), 222-307 (2013-12-26)
This review addresses the oncopharmacological properties of curcumin at the molecular level. First, the interactions between curcumin and its molecular targets are addressed on the basis of curcumin's distinct chemical properties, which include H-bond donating and accepting capacity of the
Shahar Lev-Ari et al.
The Journal of nutritional biochemistry, 25(8), 843-850 (2014-05-20)
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality. Curcumin is involved in various biological pathways leading to inhibition of NSCLC growth. The purpose of this study was to evaluate the effect of curcumin on expression of
Bharat B Aggarwal et al.
Molecular nutrition & food research, 57(9), 1529-1542 (2013-07-13)
Turmeric, a dried powder derived from the rhizome of Curcuma longa, has been used for centuries in certain parts of the world and has been linked to numerous biological activities including antioxidant, anti-inflammatory, anticancer, antigrowth, anti-arthritic, anti-atherosclerotic, antidepressant, anti-aging, antidiabetic
Yoshikane Yamauchi et al.
Phytotherapy research : PTR, 28(5), 728-735 (2013-08-15)
Resistance to erlotinib in lung cancer cases includes T790M mutant epidermal growth factor receptor and c-Met gene amplification, but other unknown mechanisms account for about 30% of the resistance. Activation of the nuclear factor kappa B (NFkappaB)-related pathways in association
Vivian Soetikno et al.
Drug discovery today, 18(15-16), 756-763 (2013-05-09)
Diabetic nephropathy is characterized by a plethora of signaling abnormalities. Recent trials have suggested that intensive glucose-lowering treatment leads to hypoglycemic events, which can be dangerous. Curcumin is the active ingredient of turmeric, which has been widely used in many

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