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29208

(N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦

Name: (N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦
Brand: SIAL

for protein sequence analysis (by MALDI-MS), ≥98.5%

别名:

N-琥珀酰亚胺基[三(2,4,6-三甲氧苯基)磷基]溴乙酸酯, TMPP-Ac-OSu

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About This Item

经验公式（希尔记法）:

C₃₃H₃₉BrNO₁₃P

CAS号:

226409-58-1

分子量:

768.54

MDL编号:

MFCD03095505

UNSPSC代码:

41116105

PubChem化学物质编号:

329753320

NACRES:

NA.21

等级

for protein sequence analysis (by MALDI-MS)

质量水平

100

检测方案

≥98.5% (HPLC)
≥98.5%

技术

MALDI-MS: suitable

mp

199-205 °C (dec.)

储存温度

−20°C

SMILES字符串

[Br-].COc1cc(OC)c(c(OC)c1)[P+](CC(=O)ON2C(=O)CCC2=O)(c3c(OC)cc(OC)cc3OC)c4c(OC)cc(OC)cc4OC

InChI

1S/C33H39NO13P.BrH/c1-38-19-12-22(41-4)31(23(13-19)42-5)48(18-30(37)47-34-28(35)10-11-29(34)36,32-24(43-6)14-20(39-2)15-25(32)44-7)33-26(45-8)16-21(40-3)17-27(33)46-9;/h12-17H,10-11,18H2,1-9H3;1H/q+1;/p-1

InChI key

YKMSQZIYVKTUHI-UHFFFAOYSA-M

一般描述

N-琥珀酰亚胺基-三(2,4,6-三甲氧苯基)磷基溴乙酸酯（TMPP-Ac-OSu）是一种酰化试剂，通常用于肽的N端α-氨基的选择性衍生化。即使不使用自动计算方法，TMPP乙酰化的肽也会发生断裂，从而产生a型离子，使获得序列信息变得更加容易。在N端肽段的液相色谱偶联质谱（LC-MS/MS）分析中，它可以用作标记试剂，提高电离效率、简化片段化和保留时间，从而更好地分离肽段。

应用

在串联质谱法中，TMPP-Ac-OSu被用于标记肽，以便将精氨酸转化为鸟氨酸，从而改善肽的片段化模式。

包装

无底玻璃瓶。内容物在插入式融锥内。

其他说明

肽 N-末端改性试剂，用于快原子轰击 (FAB) 或基质辅助激光解吸/电离质谱 (MALDI MS)

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol.

Gallien S

Genome Research, 19 (1), 128-135 (2009)

Conversion of arginine to ornithine for improving the fragmentation pattern of peptides labeled with the N-terminal tris (2, 4, 6-trimethoxyphenyl) phosphonium group in tandem mass spectrometry.

Kuyama H

Analytical Methods : Advancing Methods and Applications, 2 (11), 1792-1797 (2010)

Z. Huang et al.

Analytical Biochemistry, 69, 137-137 (1997)

Protein sequencing by matrix-assisted laser desorption ionization-postsource decay-mass spectrometry analysis of the N-Tris(2,4,6-trimethoxyphenyl)phosphine-acetylated tryptic digests.

Z H Huang et al.

Analytical biochemistry, 268(2), 305-317 (1999-03-17)

We have recently reported a simple procedure by which low picomole quantities of peptides can be modified to the corresponding N-Tris(2, 4,6-trimethoxyphenyl)phosphonium-acetyl (TMPP-Ac) derivatives (Z. H Huang, J. Wu, D. A. Gage, and J. T. Watson, Anal. Chem. 69, 137-144

A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry.

M Lisa Manier et al.

Journal of mass spectrometry : JMS, 49(8), 665-673 (2014-07-22)

Imaging mass spectrometry (IMS) studies increasingly focus on endogenous small molecular weight metabolites and consequently bring special analytical challenges. Since analytical tissue blanks do not exist for endogenous metabolites, careful consideration must be given to confirm molecular identity. Here, we

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