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MAB4401

Sigma-Aldrich

Anti-Oct-4 Antibody, clone 10H11.2

clone 10H11.2, Chemicon®, from mouse

别名:

Octamer-binding transcription factor 3, POU class 5 homeobox 1, POU domain class 5, transcription factor 1, POU domain, class 5, transcription factor 1, POU-type homeodomain-containing DNA-binding protein, octamer-binding transcription factor-3

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1 EA
¥17,995.25

¥17,995.25

预计发货时间2025年5月30日详情

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1 EA
¥17,995.25

About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

¥17,995.25

预计发货时间2025年5月30日详情

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生物来源

mouse

抗体形式

purified antibody

克隆

10H11.2, monoclonal

种属反应性

human

制造商/商品名称

Chemicon®

技术

ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
western blot: suitable

输入

sample type induced pluripotent stem cell(s)
sample type: human embryonic stem cell(s)

同位素/亚型

IgG1

NCBI登记号

NM_002701.4

UniProt登记号

Q01860

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1 of 4

此商品
69947M51626310OP
3-吗啉丙磺酸 ≥99.5% (titration)

M1254

3-吗啉丙磺酸

3-吗啉丙磺酸 BioUltra, ≥99.5% (titration)

69947

3-吗啉丙磺酸

3-吗啉丙磺酸 BioXtra, ≥99.5% (titration)

M5162

3-吗啉丙磺酸

MOPS OmniPur® Grade, >=99.0%

6310OP

MOPS

assay

≥99.5% (titration)

assay

≥99.5% (titration)

assay

≥99.5% (titration)

assay

-

Quality Level

200

Quality Level

200

Quality Level

400

Quality Level

100

form

crystalline powder

form

powder or crystals

form

powder

form

crystalline powder (Fine)

application(s)

clinical research
diagnostic assay manufacturing
life science and biopharma

application(s)

-

application(s)

diagnostic assay manufacturing

application(s)

-

storage temp.

room temp

storage temp.

-

storage temp.

room temp

storage temp.

-

一般描述

Octamer-4 (Oct-4), a member of the POU family of transcription factors, has been demonstrated to be vital for the formation of self-renewing pluripotent stem cells. During embryogenesis expression of Oct-4 is limited to pluripotent cells of the inner cell mass (ICM) that contribute to the formation of all fetal cell types. This relationship between Oct-4 and pluripotency has seen this transcription factor emerge as a marker of pluripotent stem cells. Undifferentiated human and murine pluripotent Embryonic Stem (ES) and Embryonic Carcinoma (EC) cells express Oct-4. Additionally, murine Embryonic Germ (EG) cells are also known to express Oct-4. Following stem cell differentiation, the level of Oct-4 expression decreases. Oct-4 expression by human EG cells is not known.
Purified monoclonal antibody for the detection of Human Oct-4.

特异性

Reacts with human Oct-4 only, and detects the Oct-4A isoform. (Note: Please order Catalog No. MAB4419 for use with mouse embryonic stem cells).
The clone reacts strongly with specific nuclear binding to human ES cells and cross-reacts weakly with mouse ES cells.

应用

Detect Oct-4 using this Anti-Oct-4 Antibody, clone 10H11.2 validated for use in WB, FC, IC, ELISA.
Flow Cytometry: A previous lot of this antibody was used in FC.

ELISA: A previous lot of this antibody was used in ELISA.

Immunocytochemistry: A previous lot of this antibody was used in IC. H9 cells in culture on a mouse embronic fibroblast feeder layer were labeled by a standard indirect IF protocol. Oct-4 labelling in green, DAPI in blue, & SSEA-3 (MAB4303 in red).

Optimal working dilutions must be determined by the end user.

质量

Evaluated by western blot on mouse P1 brain lysates.

Western Blotting: 1:500 dilution of this antibody detected Oct-4 on 10 µg of mouse P1 brain lysates

目标描述

44 kDa

外形

Format: Purified

分析说明

Control
Human embryonic stem cell lysate.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Microporous membrane growth substrates for embryonic stem cell culture and differentiation.
Steven D Sheridan,Sonia Gil,Matthew Wilgo,Aldo Pitt
Methods in Cell Biology null
Efficient derivation of embryonic stem cells from nuclear transfer and parthenogenetic embryos derived from cryopreserved oocytes.
Sung LY, Chang CC, Amano T, Lin CJ, Amano M, Treaster SB, Xu J, Chang WF, Nagy ZP, Yang X, Tian XC
Cellular Reprogramming null
Lingjun Rao et al.
Nature communications, 9(1), 126-126 (2018-01-11)
The generation of functional skeletal muscle tissues from human pluripotent stem cells (hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) via transient overexpression of Pax7 in paraxial mesoderm cells differentiated from hPSCs. In 2D culture
Chen Liu et al.
PloS one, 9(9), e108239-e108239 (2014-09-27)
Annulus fibrosus (AF) injuries can lead to substantial deterioration of intervertebral disc (IVD) which characterizes degenerative disc disease (DDD). However, treatments for AF repair/regeneration remain challenging due to the intrinsic heterogeneity of AF tissue at cellular, biochemical, and biomechanical levels.
Loyal A Goff et al.
PloS one, 4(9), e7192-e7192 (2009-09-29)
MicroRNAs are required for maintenance of pluripotency as well as differentiation, but since more microRNAs have been computationally predicted in genome than have been found, there are likely to be undiscovered microRNAs expressed early in stem cell differentiation. SOLiD ultra-deep
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