质量水平
检测方案
99%
形式
powder
反应适用性
reaction type: solution phase peptide synthesis
颜色
beige
mp
118-122 °C (lit.)
应用
peptide synthesis
SMILES字符串
OC(=O)CNC(=O)OCc1ccccc1
InChI
1S/C10H11NO4/c12-9(13)6-11-10(14)15-7-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,14)(H,12,13)
InChI key
CJUMAFVKTCBCJK-UHFFFAOYSA-N
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一般描述
Z-Gly-OH又名N-苄氧羰基甘氨酸, 是一种氨基酸，广泛用于液相法多肽合成。
应用
Z-Gly-OH是多功能试剂，可合成各种化合物：
- 甘氨酸衍生肽，如Z-Gly-DL-Ala-OBzl和Z-Gly-L-Ala-OBzl
- 甘氨酸N-取代酰胺，如甘氨酸-N-甲酰胺盐酸和甘氨酸-N-异丙酰胺盐酸
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Studies on Separation of Amino Acids and Related Compounds. V. A Racemization Test in Peptide Synthesis by the Use of an Amino Acid Analyzer
Bulletin of the Chemical Society of Japan, 44, 3391-3395 (1971)
Formation of peptide bonds in the coordination sphere of cobalt (III)
Journal of the American Chemical Society, 89, 6096-6103 (1967)
Duality of mechanism in the tetramethylfluoroformamidinium hexafluorophosphate-mediated synthesis of N-benzyloxycarbonylamino acid fluorides.
R Fiammengo et al.
The Journal of organic chemistry, 66(17), 5905-5910 (2001-08-21)
G K Scriba et al.
The Journal of pharmacy and pharmacology, 51(5), 549-553 (1999-07-20)
Glycine, which has weak anticonvulsant properties, has been shown to potentiate the activity of several antiepileptic drugs but not phenytoin. Recently, studies have shown that N-(benzyloxycarbonyl)glycine (Z-glycine) antagonized seizures more than glycine in addition to possessing activity in the maximal
D M Lambert et al.
Neuroreport, 5(7), 777-780 (1994-03-21)
Although glycine does not cross easily the blood-brain barrier, it exhibits at very high doses (10-40 mmol kg-1) a modest anticonvulsant activity. In this study, carbamate derivatives--N-benzyloxycarbonylglycine (Z-glycine) and N,tert-butoxycarbonylglycine (Boc-glycine)--have been compared with glycine. Z-glycine (1 mmol kg-1), but
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