Porous silicon advances in drug delivery and immunotherapy.

Porous silicon advances in drug delivery and immunotherapy.

Current opinion in pharmacology (2013-07-13)

David J Savage, Xuewu Liu, Steven A Curley, Mauro Ferrari, Rita E Serda

摘要

Biomedical applications of porous silicon include drug delivery, imaging, diagnostics and immunotherapy. This review summarizes new silicon particle fabrication techniques, dynamics of cellular transport, advances in the multistage vector approach to drug delivery, and the use of porous silicon as immune adjuvants. Recent findings support superior therapeutic efficacy of the multistage vector approach over single particle drug delivery systems in mouse models of ovarian and breast cancer. With respect to vaccine development, multivalent presentation of pathogen-associated molecular patterns on the particle surface creates powerful platforms for immunotherapy, with the porous matrix able to carry both antigens and immune modulators.

材料

货号

品牌

产品描述

215619

Sigma-Aldrich

硅, powder, −325 mesh, 99% trace metals basis

646687

Sigma-Aldrich

硅, wafer (single side polished), <100>, N-type, contains no dopant, diam. × thickness 2 in. × 0.5 mm

633097

Sigma-Aldrich

硅, nanopowder, <100 nm particle size (TEM), ≥98% trace metals basis

647101

Sigma-Aldrich

硅, wafer (single side polished), <111>, N-type, contains no dopant, diam. × thickness 2 in. × 0.5 mm

647764

Sigma-Aldrich

硅, wafer (single side polished), <100>, P-type, contains boron as dopant, diam. × thickness 3 in. × 0.5 mm

647675

Sigma-Aldrich

硅, wafer (single side polished), <100>, P-type, contains boron as dopant, diam. × thickness 2 in. × 0.5 mm

647535

Sigma-Aldrich

硅, wafer (single side polished), <100>, N-type, contains no dopant, diam. × thickness 3 in. × 0.5 mm

343250

Sigma-Aldrich

硅, pieces, 99.95% trace metals basis

647780

Sigma-Aldrich

硅, wafer (single side polished), <100>, N-type, contains phosphorus as dopant, diam. × thickness 2 in. × 0.5 mm

647543

Sigma-Aldrich

硅, wafer (single side polished), <111>, N-type, contains no dopant, diam. × thickness 3 in. × 0.5 mm

647799

Sigma-Aldrich

硅, wafer (single side polished), <111>, N-type, contains phosphorus as dopant, diam. × thickness 2 in. × 0.5 mm

647802

Sigma-Aldrich

硅, wafer (single side polished), <100>, N-type, contains phosphorus as dopant, diam. × thickness 3 in. × 0.5 mm

647705

Sigma-Aldrich

硅, wafer, <111>, P-type, contains boron as dopant, diam. × thickness 2 in. × 0.3 mm

647772

Sigma-Aldrich

硅, wafer (single side polished), <111>, P-type, contains boron as dopant, diam. × thickness 3 in. × 0.5 mm

GF91141792

硅, sheet, 10x10mm, thickness 0.5mm, single crystal, -100, 100%

GF71817543

硅, sheet, 10x10mm, thickness 0.6mm, single crystal, -100, 100%

GF46268433

硅, disks, 15.9mm, thickness 0.38mm, single crystal, n-type, 100%

GF64686998

硅, rod, 100mm, diameter 2.0mm, crystalline, 100%

GF05482852

硅, rod, 50mm, diameter 2.0mm, crystalline, 100%

GF04814951

硅, rod, 100mm, diameter 25mm, crystalline, 100%

GF37993595

硅, rod, 100mm, diameter 10.0mm, single crystal - random orientation, 100%

GF73529051

硅, sheet, 52x52mm, thickness 1.0mm, polycrystalline, 99.999%

GF10907377

硅, rod, 80mm, diameter 20mm, single crystal, -100, 99.999%

GF20311254

硅, sheet, 25x25mm, thickness 1.0mm, polycrystalline, 99.999%

GF64342188

硅, rod, 50mm, diameter 6mm, single crystal, -111, 99.999%

GF16286227

硅, disks, 15.9mm, thickness 0.38mm, single crystal, n-type, 100%

GF14076930

硅, rod, 50mm, diameter 5.0mm, crystalline, 100%

GF16363391

硅, rod, 10mm, diameter 2.0mm, crystalline, 100%

GF70438518

硅, rod, 40mm, diameter 20mm, single crystal, -100, 99.999%

GF43555664

硅, rod, 25mm, diameter 3.15mm, single crystal - random orientation, 100%