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Merck
CN
  • CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

Nature neuroscience (2013-05-28)
Elizabeth M Bradshaw, Lori B Chibnik, Brendan T Keenan, Linda Ottoboni, Towfique Raj, Anna Tang, Laura L Rosenkrantz, Selina Imboywa, Michelle Lee, Alina Von Korff, Martha C Morris, Denis A Evans, Keith Johnson, Reisa A Sperling, Julie A Schneider, David A Bennett, Philip L De Jager
PMID23708142
摘要

In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.

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品牌
产品描述
31392
Sigma-Aldrich
葡聚糖 来源于明串珠菌 属, Mr 450,000-650,000
31390
Sigma-Aldrich
葡聚糖 来源于明串珠菌 属, Mr ~70,000
31389
Sigma-Aldrich
葡聚糖 来源于明串珠菌 属, Mr ~40,000
D5376
Sigma-Aldrich
葡聚糖 来源于肠系膜明串珠菌, average mol wt 1,500,000-2,800,000
D9260
Sigma-Aldrich
葡聚糖 来源于肠系膜明串珠菌, average mol wt 9,000-11,000
D1662
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葡聚糖 来源于肠系膜明串珠菌, average mol wt 35,000-45,000
D8821
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葡聚糖 来源于肠系膜明串珠菌, average mol wt 60,000-76,000
31388
Sigma-Aldrich
葡聚糖 来源于明串珠菌 属, Mr ~6,000
D4876
Sigma-Aldrich
葡聚糖 来源于肠系膜明串珠菌, average mol wt 150,000
00271
Supelco
右旋糖酐, analytical standard, for GPC, 25,000
09184
Sigma-Aldrich
葡聚糖 来源于明串珠菌 属, Mr ~100,000
D8802
Sigma-Aldrich
葡聚糖 溶液 来源于肠系膜明串珠菌, 20 % (w/w) (Autoclaved)
00269
Supelco
右旋糖酐, analytical standard, for GPC, 5,000
31398
Sigma-Aldrich
葡聚糖 来源于肠系膜明串珠菌, Mr ~200,000
31425
Supelco
葡聚糖 来源于肠系膜明串珠菌, analytical standard, for GPC, Mw 670,000
00268
Supelco
右旋糖酐, analytical standard, for GPC, 1,000
31387
Sigma-Aldrich
葡聚糖 来源于明串珠菌 属, Mr 15,000-25,000
31397
Sigma-Aldrich
葡聚糖 来源于肠系膜明串珠菌, Mr ~60,000
31394
Sigma-Aldrich
右旋糖酐, enzymatic synth.
00894
Supelco
右旋糖酐, analytical standard, for GPC, 270,000
31417
Supelco
葡聚糖 来源于肠系膜明串珠菌, analytical standard, for GPC, Mw 5,000
00893
Supelco
右旋糖酐, analytical standard, for GPC, 150,000
00895
Supelco
右旋糖酐, analytical standard, for GPC, 410,000
31419
Supelco
葡聚糖 来源于肠系膜明串珠菌, analytical standard, for GPC, Mw 25,000
00891
Supelco
右旋糖酐, analytical standard, for GPC, 50,000
D3759
Sigma-Aldrich
葡聚糖 来源于肠系膜明串珠菌, average mol wt 48,000-90,000
31430
Supelco
右旋糖酐, analytical standard, for GPC, Set Mp 1,000-400,000
31416
Supelco
葡聚糖 来源于肠系膜明串珠菌, analytical standard, for GPC, Mw 1,000
D4626
Sigma-Aldrich
葡聚糖 来源于肠系膜明串珠菌, average mol wt 15,000-30,000
00892
Supelco
右旋糖酐, analytical standard, for GPC, 80,000