N7389
3-硝基-L-酪氨酸
Oxidant, crystalline
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关于此项目
线性分子式:
O2NC6H3-4-(OH)CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
226.19
NACRES:
NA.32
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352200
EC Number:
210-688-6
MDL number:
Beilstein/REAXYS Number:
2813157
Application
3-硝基-L-酪氨酸已用于：
- 蛋白质印迹分析，定量分析小鼠组织蛋白中的硝基酪氨酸水平
- Murashige–Skoog培养基，用于处理野生型和丝裂原活化蛋白激酶6 (mpk6)-2突变体幼苗，推断一氧化氮(NO)和MPK6在调节有丝分裂微管组织中的功能联系
- 免疫细胞化学
Biochem/physiol Actions
3-硝基-L-酪氨酸是一种氧化剂和细胞毒剂。在全身性自免疫疾病患者体内，3-硝基酪氨酸可作为氮自由基改性蛋白质的生物标记物。它是过氧亚硝酸盐介导的氧化损伤的标志物。硝基酪氨酸与乳腺癌患者体内的VEGF-C表达和淋巴结转移有关。3-硝基酪氨酸由氧化/亚硝化压力介导的化学改性（如在肺癌发生中观测到的蛋白质硝化）产生。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Thalidomide can modulate the TNFα-NFκB and iNOS pathway, which involve in the pathogenesis of hepatopulmonary syndrome (HPS) and muscle wasting in cirrhosis. In bile duct ligated-cirrhotic rats, the increased circulating CD16+ (inflammatory) monocytes and its intracellular TNFα, NFκB, monocyte chemotactic
Eman Ahmed Alaa El-Din et al.
Environmental science and pollution research international, 26(21), 21556-21564 (2019-05-28)
The evaluation of the toxicological effects of titanium dioxide nanoparticles (TiO2NPs) is increasingly important due to their growing occupational and industrial use. Curcumin is a yellow curry spice with a long history of use in herbal medicine and has numerous
Jiqu Xu et al.
Journal of pineal research, 67(2), e12584-e12584 (2019-05-03)
Brain insulin resistance, induced by neuroinflammation and oxidative stress, contributes to neurodegeneration, that is, processes that are associated with Aβ accumulation and TAU hyperphosphorylation. Here, we tested the effect of chronic administration of melatonin (MLT) on brain insulin resistance and
Ana C Andreazza et al.
Journal of neurochemistry, 127(4), 552-561 (2013-05-23)
Previously, we found decreased mitochondrial complex I subunits levels and increased protein oxidation and nitration in postmortem prefrontal cortex (PFC) from patients with bipolar disorder (BD) and schizophrenia (SCZ). The objectives of this study were to replicate our findings in
Maren Carstensen et al.
European journal of clinical investigation, 43(4), 350-357 (2013-02-13)
Secreted frizzled-related protein 5 (Sfrp5) has been described as novel adipokine in mice with insulin-sensitising and anti-inflammatory properties similar to adiponectin. The aim of this study was to compare serum concentrations and determinants of Sfrp5, its pro-inflammatory antagonist wingless-type MMTV
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