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Merck
CN

N7389

Sigma-Aldrich

3-硝基-L-酪氨酸

crystalline

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About This Item

线性分子式:
O2NC6H3-4-(OH)CH2CH(NH2)CO2H
CAS号:
分子量:
226.19
Beilstein:
2813157
EC 号:
MDL编号:
UNSPSC代码:
12352200
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.32

表单

crystalline

质量水平

mp

233-235 °C (dec.) (lit.)

SMILES字符串

N[C@@H](Cc1ccc(O)c(c1)[N+]([O-])=O)C(O)=O

InChI

1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)/t6-/m0/s1

InChI key

FBTSQILOGYXGMD-LURJTMIESA-N

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应用

3-硝基-L-酪氨酸已用于:
  • 蛋白质印迹分析,定量分析小鼠组织蛋白中的硝基酪氨酸水平
  • Murashige–Skoog培养基,用于处理野生型和丝裂原活化蛋白激酶6 (mpk6)-2突变体幼苗,推断一氧化氮(NO)和MPK6在调节有丝分裂微管组织中的功能联系
  • 免疫细胞化学

生化/生理作用

3-硝基-L-酪氨酸是一种氧化剂和细胞毒剂。在全身性自免疫疾病患者体内,3-硝基酪氨酸可作为氮自由基改性蛋白质的生物标记物。它是过氧亚硝酸盐介导的氧化损伤的标志物。硝基酪氨酸与乳腺癌患者体内的VEGF-C表达和淋巴结转移有关。3-硝基酪氨酸由氧化/亚硝化压力介导的化学改性(如在肺癌发生中观测到的蛋白质硝化)产生。

相关产品

产品编号
说明
价格

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

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