N7389
3-硝基-L-酪氨酸
Oxidant, crystalline
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关于此项目
线性分子式:
O2NC6H3-4-(OH)CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
226.19
NACRES:
NA.32
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352200
EC Number:
210-688-6
MDL number:
Beilstein/REAXYS Number:
2813157
产品名称
3-硝基-L-酪氨酸, crystalline
InChI key
FBTSQILOGYXGMD-LURJTMIESA-N
InChI
1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)/t6-/m0/s1
SMILES string
N[C@@H](Cc1ccc(O)c(c1)[N+]([O-])=O)C(O)=O
form
crystalline
mp
233-235 °C (dec.) (lit.)
Quality Level
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相关类别
Application
3-硝基-L-酪氨酸已用于：
- 蛋白质印迹分析，定量分析小鼠组织蛋白中的硝基酪氨酸水平
- Murashige–Skoog培养基，用于处理野生型和丝裂原活化蛋白激酶6 (mpk6)-2突变体幼苗，推断一氧化氮(NO)和MPK6在调节有丝分裂微管组织中的功能联系
- 免疫细胞化学
Biochem/physiol Actions
3-硝基-L-酪氨酸是一种氧化剂和细胞毒剂。在全身性自免疫疾病患者体内，3-硝基酪氨酸可作为氮自由基改性蛋白质的生物标记物。它是过氧亚硝酸盐介导的氧化损伤的标志物。硝基酪氨酸与乳腺癌患者体内的VEGF-C表达和淋巴结转移有关。3-硝基酪氨酸由氧化/亚硝化压力介导的化学改性（如在肺癌发生中观测到的蛋白质硝化）产生。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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