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Merck
CN

H5653

8-羟基-2′-脱氧鸟苷

≥98% (TLC), DNA damage biomaker

别名:

8-氧代-7,8-二氢-2′-脱氧鸟苷, 8-氧代-dG

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关于此项目

经验公式（希尔记法）:
C10H13N5O5
化学文摘社编号:
88847-89-6
分子量:
283.24
MDL编号:
MFCD00210311
UNSPSC代码:
12352200
PubChem化学物质编号:
24895702
NACRES:
NA.77

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产品名称

8-羟基-2′-脱氧鸟苷, ≥98% (TLC)

质量水平

200

方案

≥98% (TLC)

储存温度

2-8°C

SMILES字符串

O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1

InChI

1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)

InChI key

HCAJQHYUCKICQH-UHFFFAOYSA-N

相关类别

应用

8-羟基-2′-脱氧鸟苷已用于以下情形：
  • 作为标准品，通过电化学检测分析正常和异常妊娠胎盘中的氧化DNA损伤
  • 借助电化学检测(ECD)，作为标准品用于高效液相色谱法(HPLC)
  • 作为HPLC标准品和氧化应激尿液标志物，评估绿咖啡豆提取物的潜在抗氧化活性(GCBE) 体内
  • 作为标准品用于LC/MS/MS分析

生化/生理作用

8-羟基-2′-脱氧鸟苷的水平有助于评估喉癌个体的氧化应激和DNA损伤。因此它可以用作活性氧(ROS)诱导DNA损伤的主要生物标志物。
标记化合物通常指示与诱变和致癌作用相关的DNA损伤

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000424169
0000424169
0000395821
0000378364
0000378364

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Aireza Shirpoor et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 698-704 (2016-10-07)
Chronic alcohol ingestion is associated with pronounced detrimental effects on the renal system. In the current study, the protective effect of ginger extract on ethanol-induced damage was evaluated through determining 8-OHdG, cystatin C, glomerular filtration rate, and pathological changes such
Arif Malik et al.
Drug design, development and therapy, 12, 1431-1443 (2018-06-07)
The present study investigates the hepato- and DNA-protective effects of standardized extracts of Cleome brachycarpa (cabralealactone), Solanum incanum (solasodin), and Salvadora oleioides (salvadorin) in rats. Hepatotoxicity was induced with intraperitoneal injection of carbon tetrachloride (CCl4) (1 mL/kg b.wt.) once a
Increased blood 8-hydroxy-2-deoxyguanosine levels in methamphetamine users during early abstinence
Huang M C, et al.
The American Journal of Drug and Alcohol Abuse, 44(3), 395-402 (2018)
Liang Cui et al.
Chemical research in toxicology, 26(2), 195-202 (2012-11-13)
Oxidative damage to DNA has many origins, including irradiation, inflammation, and oxidative stress, but the chemistries are not the same. The most oxidizable base in DNA is 2-deoxyguanosine (dG), and the primary oxidation products are 8-oxodG and 2-amino-imidazolone. The latter
Rachel Yong et al.
PloS one, 8(8), e73428-e73428 (2013-08-31)
NADPH oxidase 4 (Nox4) is reported to be the major source of reactive oxygen species (ROS) in the kidneys during the early stages of diabetic nephropathy. It has been shown to mediate TGFβ1-induced differentiation of cardiac fibroblasts into myofibroblasts. Despite
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