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Merck
CN

H5653

8-羟基-2′-脱氧鸟苷

≥98% (TLC), DNA damage biomaker

别名:

8-氧代-7,8-二氢-2′-脱氧鸟苷, 8-氧代-dG

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关于此项目

经验公式（希尔记法）:
C10H13N5O5
化学文摘社编号:
88847-89-6
分子量:
283.24
UNSPSC Code:
12352200
PubChem Substance ID:
24895702
NACRES:
NA.77
MDL number:
MFCD00210311

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产品名称

8-羟基-2′-脱氧鸟苷, ≥98% (TLC)

SMILES string

O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1

InChI key

HCAJQHYUCKICQH-UHFFFAOYSA-N

InChI

1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)

assay

≥98% (TLC)

storage temp.

2-8°C

Quality Level

200

相关类别

Application

8-羟基-2′-脱氧鸟苷已用于以下情形：
  • 作为标准品，通过电化学检测分析正常和异常妊娠胎盘中的氧化DNA损伤
  • 借助电化学检测(ECD)，作为标准品用于高效液相色谱法(HPLC)
  • 作为HPLC标准品和氧化应激尿液标志物，评估绿咖啡豆提取物的潜在抗氧化活性(GCBE) 体内
  • 作为标准品用于LC/MS/MS分析

Biochem/physiol Actions

8-羟基-2′-脱氧鸟苷的水平有助于评估喉癌个体的氧化应激和DNA损伤。因此它可以用作活性氧(ROS)诱导DNA损伤的主要生物标志物。
标记化合物通常指示与诱变和致癌作用相关的DNA损伤

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000424169
0000424169
0000395821
0000378364
0000378364

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Arif Malik et al.
Drug design, development and therapy, 12, 1431-1443 (2018-06-07)
The present study investigates the hepato- and DNA-protective effects of standardized extracts of Cleome brachycarpa (cabralealactone), Solanum incanum (solasodin), and Salvadora oleioides (salvadorin) in rats. Hepatotoxicity was induced with intraperitoneal injection of carbon tetrachloride (CCl4) (1 mL/kg b.wt.) once a
Increased blood 8-hydroxy-2-deoxyguanosine levels in methamphetamine users during early abstinence
Huang M C, et al.
The American Journal of Drug and Alcohol Abuse, 44(3), 395-402 (2018)
Aireza Shirpoor et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 698-704 (2016-10-07)
Chronic alcohol ingestion is associated with pronounced detrimental effects on the renal system. In the current study, the protective effect of ginger extract on ethanol-induced damage was evaluated through determining 8-OHdG, cystatin C, glomerular filtration rate, and pathological changes such
Urine metabolomics shows an induction of fatty acids metabolism in healthy adult volunteers after supplementation with green coffee (Coffea robusta L.) bean extract
Peron G, et al.
Phytomedicine, 38(1), 74-83 (2018)
Rachel Yong et al.
PloS one, 8(8), e73428-e73428 (2013-08-31)
NADPH oxidase 4 (Nox4) is reported to be the major source of reactive oxygen species (ROS) in the kidneys during the early stages of diabetic nephropathy. It has been shown to mediate TGFβ1-induced differentiation of cardiac fibroblasts into myofibroblasts. Despite
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