推荐产品
质量水平
检测方案
≥98% (TLC)
储存温度
2-8°C
SMILES字符串
O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1
InChI
1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)
InChI key
HCAJQHYUCKICQH-UHFFFAOYSA-N
应用
8-羟基-2′-脱氧鸟苷已用于以下情形：
- 作为标准品，通过电化学检测分析正常和异常妊娠胎盘中的氧化DNA损伤
- 借助电化学检测(ECD)，作为标准品用于高效液相色谱法(HPLC)
- 作为HPLC标准品和氧化应激尿液标志物，评估绿咖啡豆提取物的潜在抗氧化活性(GCBE) 体内
- 作为标准品用于LC/MS/MS分析
生化/生理作用
8-羟基-2′-脱氧鸟苷的水平有助于评估喉癌个体的氧化应激和DNA损伤。因此它可以用作活性氧(ROS)诱导DNA损伤的主要生物标志物。
标记化合物通常指示与诱变和致癌作用相关的DNA损伤
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Elisabeth Müllner et al.
Molecular nutrition & food research, 57(2), 328-338 (2012-11-14)
Type 2 diabetes is a multifactorial disease associated with increased oxidative stress, which may lead to increased DNA damage. The aim of this study was to investigate the effect of a healthy diet on DNA oxidation in diabetics and nondiabetics.
Pan Chen et al.
Life sciences, 232, 116594-116594 (2019-06-25)
Sleep deficiency has been reported to be associated with some oral health problems. Oral ulcers are very common lesions of the oral mucosa, which severely impact patients' quality of life. However, the association between sleep deficiency and the oral ulcer
Rachel Yong et al.
PloS one, 8(8), e73428-e73428 (2013-08-31)
NADPH oxidase 4 (Nox4) is reported to be the major source of reactive oxygen species (ROS) in the kidneys during the early stages of diabetic nephropathy. It has been shown to mediate TGFβ1-induced differentiation of cardiac fibroblasts into myofibroblasts. Despite
Liang Cui et al.
Chemical research in toxicology, 26(2), 195-202 (2012-11-13)
Oxidative damage to DNA has many origins, including irradiation, inflammation, and oxidative stress, but the chemistries are not the same. The most oxidizable base in DNA is 2-deoxyguanosine (dG), and the primary oxidation products are 8-oxodG and 2-amino-imidazolone. The latter
Effects of the Phosphodiesterase-5 (PDE-5) Inhibitors, Avanafil and Zaprinast, on Bone Remodeling and Oxidative Damage in a Rat Model of Glucocorticoid-Induced Osteoporosis
Huyut Z, et al.
Medical Science Monitor Basic Research, 24(1), 47-47 (2018)
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