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H5653

Sigma-Aldrich

8-羟基-2′-脱氧鸟苷

≥98% (TLC), DNA damage biomaker

别名:

8-氧代-7,8-二氢-2′-脱氧鸟苷, 8-氧代-dG

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25 μL
CN¥2,199.22
4 X 25 μL
CN¥1,358.69

CN¥2,199.22

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25 μL
CN¥2,199.22
4 X 25 μL
CN¥1,358.69

About This Item

经验公式（希尔记法）:
C10H13N5O5
CAS号:
88847-89-6
分子量:
283.24
MDL编号:
MFCD00210311
UNSPSC代码:
12352200
PubChem化学物质编号:
24895702
NACRES:
NA.77

CN¥2,199.22

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产品名称

8-羟基-2′-脱氧鸟苷, ≥98% (TLC)

质量水平

200

方案

≥98% (TLC)

储存温度

2-8°C

SMILES字符串

O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1

InChI

1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)

InChI key

HCAJQHYUCKICQH-UHFFFAOYSA-N

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Anti-HMGB1 Antibody, clone 3K6, ZooMAb® Rabbit Monoclonal

biological source

rabbit (recombinant)

biological source

rabbit (recombinant)

biological source

rabbit (recombinant)

biological source

rabbit (recombinant)

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

species reactivity

human

species reactivity

human, rat, mouse

species reactivity

mouse, human, rat

species reactivity

mouse, human

clone

10B13, monoclonal, recombinant monoclonal

clone

2E8, monoclonal, recombinant monoclonal

clone

1K4, recombinant monoclonal

clone

3K6, recombinant monoclonal

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

Gene Information

human ... GAPDH(2597)

Gene Information

human ... GFAP(2670)

Gene Information

rat ... Gria2;Glur2(29627)

Gene Information

human ... HMGB1;HMG1(3146)

应用

8-羟基-2′-脱氧鸟苷已用于以下情形：
  • 作为标准品，通过电化学检测分析正常和异常妊娠胎盘中的氧化DNA损伤[1]
  • 借助电化学检测(ECD)，作为标准品用于高效液相色谱法(HPLC)[2]
  • 作为HPLC标准品和氧化应激尿液标志物，评估绿咖啡豆提取物的潜在抗氧化活性(GCBE) 体内[3]
  • 作为标准品用于LC/MS/MS分析[4]

生化/生理作用

8-羟基-2′-脱氧鸟苷的水平有助于评估喉癌个体的氧化应激和DNA损伤。[5]因此它可以用作活性氧(ROS)诱导DNA损伤的主要生物标志物。[6]
标记化合物通常指示与诱变和致癌作用相关的DNA损伤

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000395821
    0000378364
    0000378364
    0000395821
    0000238923

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    Effects of the Phosphodiesterase-5 (PDE-5) Inhibitors, Avanafil and Zaprinast, on Bone Remodeling and Oxidative Damage in a Rat Model of Glucocorticoid-Induced Osteoporosis
    Huyut Z, et al.
    Medical Science Monitor Basic Research, 24(1), 47-47 (2018)
    Liang Cui et al.
    Chemical research in toxicology, 26(2), 195-202 (2012-11-13)
    Oxidative damage to DNA has many origins, including irradiation, inflammation, and oxidative stress, but the chemistries are not the same. The most oxidizable base in DNA is 2-deoxyguanosine (dG), and the primary oxidation products are 8-oxodG and 2-amino-imidazolone. The latter
    Elisabeth Müllner et al.
    Molecular nutrition & food research, 57(2), 328-338 (2012-11-14)
    Type 2 diabetes is a multifactorial disease associated with increased oxidative stress, which may lead to increased DNA damage. The aim of this study was to investigate the effect of a healthy diet on DNA oxidation in diabetics and nondiabetics.
    Rachel Yong et al.
    PloS one, 8(8), e73428-e73428 (2013-08-31)
    NADPH oxidase 4 (Nox4) is reported to be the major source of reactive oxygen species (ROS) in the kidneys during the early stages of diabetic nephropathy. It has been shown to mediate TGFβ1-induced differentiation of cardiac fibroblasts into myofibroblasts. Despite
    Pan Chen et al.
    Life sciences, 232, 116594-116594 (2019-06-25)
    Sleep deficiency has been reported to be associated with some oral health problems. Oral ulcers are very common lesions of the oral mucosa, which severely impact patients' quality of life. However, the association between sleep deficiency and the oral ulcer
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