生物来源
Escherichia coli (F583 Rd mutant)
质量水平
形式
lyophilized powder
杂质
<0.2% Ketodeoxyoctonate (KDO)
运输
ambient
储存温度
2-8°C
生化/生理作用
脂质A分子组成了由革兰氏阴性菌所产生的内毒素的脂膜锚定核心成分。脂质A分子可诱导免疫反应。结构上，脂质A分子由两个物种依赖性、脂肪酰基链数、同一性和磷酸化程度均不同的葡糖胺单元所组成。
来自大肠杆菌F583的单磷酰基脂质A可用于对不同LPA分子和类似物内特定结构的抗原性进行比较性评估。
来自大肠杆菌F583的单磷酰基脂质A可用于对不同LPA分子和类似物内特定结构的抗原性进行比较性评估。
脂质A具有免疫刺激佐剂活性，包括巨噬细胞、T细胞和B细胞活化。研究表明脂质A对于Th2有比Th1更大的刺激。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Douglas S Watson et al.
Clinical and vaccine immunology : CVI, 18(2), 289-297 (2010-12-17)
Particulate delivery systems enhance antibody responses to subunit antigens. However, covalent attachment of protein antigens can disrupt protein structure and mask critical epitopes, altering the antibody response to the antigen. In this report, we evaluate noncovalent metal chelation via nitrilotriacetic
Vincent J Venditto et al.
Clinical and vaccine immunology : CVI, 21(8), 1086-1093 (2014-05-30)
Broadly neutralizing monoclonal antibodies (bNAbs) 2F5 and 4E10 bind to the membrane proximal external region (MPER) of gp41 and also cross-react with phospholipids. In this study, we investigated if chemical modifications on the MPER adjacent to 2F5 and 4E10 epitopes
Vincent J Venditto et al.
Clinical and vaccine immunology : CVI, 20(1), 39-45 (2012-11-02)
The inability to generate broadly neutralizing antibody (bnAb) responses to the membrane proximal external region (MPER) of HIV-1 gp41 using current vaccine strategies has hampered efforts to prevent the spread of HIV. To address this challenge, we investigated a novel
Mark B Stoddard et al.
Clinical and vaccine immunology : CVI, 17(1), 98-107 (2009-11-20)
Bacterial endotoxin interacts with the human immune system via complex immunological pathways. The evaluation of endotoxicity is important in the development of safe vaccines and immunomodulatory therapeutics. The Limulus amebocyte lysate (LAL) assay is generally accepted by the FDA for
K Olson et al.
Vaccine, 28(2), 548-560 (2009-10-20)
Herpes simplex virus type 2 (HSV2) is the most common causative agent of genital herpes, with infection rates as high as 1 in 6 adults. The present studies were done to evaluate the efficacy of a liposomal HSV2 gD(1-306) vaccine
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