生物来源
Salmonella enterica (serotype minnesota Re 595 Re mutant)
质量水平
形式
lyophilized powder
杂质
<0.2% Ketodeoxyoctonate (KDO)
运输
ambient
储存温度
2-8°C
应用
脂质A分子组成脂质膜，锚定革兰氏阴性细菌产生的内毒素的核心组分。 脂质A分子可诱导免疫反应。 在结构上，脂质A分子由两个葡萄糖胺单元组成，两者具有不同的物种依赖性脂肪酰链数、同一性和磷酸化程度。
来自肠道沙门氏菌血清型明尼苏达Re 595的单磷酰脂质A可用于比较评估不同LPA分子和类似物中特定结构的抗原性。
来自肠道沙门氏菌血清型明尼苏达Re 595的单磷酰脂质A可用于比较评估不同LPA分子和类似物中特定结构的抗原性。
生化/生理作用
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，TLR4是Toll样受体蛋白家族的成员，该家族可识别常见的病原体相关分子模式（PAMP）。
脂质A具有免疫刺激佐剂活性，包括巨噬细胞、T细胞和B细胞活化。 研究表明，脂质A对Th2的刺激性比对Th1的大。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
S Hutchison et al.
Veterinary immunology and immunopathology, 216, 109912-109912 (2019-08-26)
Melanoma in humans and canines is an aggressive and highly metastatic cancer. The mucosal forms in both species share genetic and histopathologic features, making dogs a valuable spontaneous disease animal model. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of
Tarik A Khan et al.
Science advances, 2(3), e1501371-e1501371 (2016-03-22)
High-throughput antibody repertoire sequencing (Ig-seq) provides quantitative molecular information on humoral immunity. However, Ig-seq is compromised by biases and errors introduced during library preparation and sequencing. By using synthetic antibody spike-in genes, we determined that primer bias from multiplex polymerase
Subhashini Jagu et al.
Vaccine, 28(28), 4478-4486 (2010-05-04)
Immunization with L1 as pentavalent capsomeres or virus-like particles (VLPs) generates high and long-lived titers of neutralizing antibodies and protection primarily against the human papillomavirus (HPV) type from which the vaccine was derived. Conversely, vaccination with L2 minor capsid protein
Melissa C Hanson et al.
Vaccine, 33(7), 861-868 (2015-01-07)
An HIV vaccine capable of inducing high and durable levels of broadly neutralizing antibodies has thus far proven elusive. A promising antigen is the membrane-proximal external region (MPER) from gp41, a segment of the viral envelope recognized by a number
Yanjun Zhang et al.
Antiviral research, 165, 11-22 (2019-03-02)
Respiratory syncytial virus (RSV) infection causes significant disease in the lower respiratory tract of young children, and there is currently no licensed vaccine to prevent RSV infection. The F glycoprotein is considered a major antigenic target for RSV vaccine development.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门