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L5399

Sigma-Aldrich

脂质 A，二磷酸酰 来源于大肠杆菌 F583（Rd 突变体）

别名:

二磷酰脂质A（来自大肠杆菌）

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About This Item

MDL编号:
MFCD00131510
UNSPSC代码:
12352211
PubChem化学物质编号:
24896402
NACRES:
NA.25

生物来源

Escherichia coli (F583 Rd mutant)

质量水平

200

表单

lyophilized powder

运输

ambient

储存温度

2-8°C

SMILES字符串

CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OCC2OC(OP(O)(O)=O)C(NC(=O)CC(O)CCCCCCCCCCC)C(OC(=O)CC(O)CCCCCCCCCCC)C2O)OC(CO)C1OP(O)(O)=O

InChI

1S/C94H178N2O25P2/c1-7-13-19-25-31-37-38-44-50-56-62-68-84(103)115-78(66-60-54-48-42-35-29-23-17-11-5)72-86(105)119-92-88(96-82(101)71-77(65-59-53-47-41-34-28-22-16-10-4)114-83(102)67-61-55-49-43-36-30-24-18-12-6)93(116-79(73-97)90(92)120-122(107,108)109)113-74-80-89(106)91(118-85(104)70-76(99)64-58-52-46-40-33-27-21-15-9-3)87(94(117-80)121-123(110,111)112)95-81(100)69-75(98)63-57-51-45-39-32-26-20-14-8-2/h75-80,87-94,97-99,106H,7-74H2,1-6H3,(H,95,100)(H,96,101)(H2,107,108,109)(H2,110,111,112)

InChI key

GZQKNULLWNGMCW-UHFFFAOYSA-N

相关类别

一般描述

脂质A是脂多糖(LPS)的基本结构，存在于细菌中。

应用

使用脂质A，来自大肠杆菌F583（Rd突变）的焦磷酰：
  • 研究不同脂类A分子对体外肺周细胞增殖的影响
  • 在THP-1和J774A.1细胞，分别形成新蝶呤和亚硝酸盐
  • 在结合实验中用作脂多糖(LPS)衍生物
  • 刺激脾脏细胞并为toll样受体4 (TLR4)的有丝分裂原刺激

生化/生理作用

脂质A是人体内脂多糖(LPS)强大的免疫刺激活性活动所必需的物质。脂质A是脂多糖的疏水结构域，有助于将脂多糖锚定在细菌的质膜上。它具有免疫活性，是可由免疫系统识别的脂多糖的重要组成部分。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000367391
0000367391
0000242477
0000241290
0000242477

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