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Merck
CN

L5399

脂质 A，二磷酸酰 来源于大肠杆菌 F583（Rd 突变体）

别名:

二磷酰脂质A（来自大肠杆菌）

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关于此项目

NACRES:
NA.25
PubChem Substance ID:
24896402
UNSPSC Code:
12352211
MDL number:
MFCD00131510

主要文件

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InChI key

GZQKNULLWNGMCW-UHFFFAOYSA-N

SMILES string

CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OCC2OC(OP(O)(O)=O)C(NC(=O)CC(O)CCCCCCCCCCC)C(OC(=O)CC(O)CCCCCCCCCCC)C2O)OC(CO)C1OP(O)(O)=O

InChI

1S/C94H178N2O25P2/c1-7-13-19-25-31-37-38-44-50-56-62-68-84(103)115-78(66-60-54-48-42-35-29-23-17-11-5)72-86(105)119-92-88(96-82(101)71-77(65-59-53-47-41-34-28-22-16-10-4)114-83(102)67-61-55-49-43-36-30-24-18-12-6)93(116-79(73-97)90(92)120-122(107,108)109)113-74-80-89(106)91(118-85(104)70-76(99)64-58-52-46-40-33-27-21-15-9-3)87(94(117-80)121-123(110,111)112)95-81(100)69-75(98)63-57-51-45-39-32-26-20-14-8-2/h75-80,87-94,97-99,106H,7-74H2,1-6H3,(H,95,100)(H,96,101)(H2,107,108,109)(H2,110,111,112)

biological source

Escherichia coli (F583 Rd mutant)

form

lyophilized powder

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

相关类别

General description

脂质A是脂多糖(LPS)的基本结构，存在于细菌中。

Application

使用脂质A，来自大肠杆菌F583（Rd突变）的焦磷酰：
  • 研究不同脂类A分子对体外肺周细胞增殖的影响
  • 在THP-1和J774A.1细胞，分别形成新蝶呤和亚硝酸盐
  • 在结合实验中用作脂多糖(LPS)衍生物
  • 刺激脾脏细胞并为toll样受体4 (TLR4)的有丝分裂原刺激

Biochem/physiol Actions

脂质A是人体内脂多糖(LPS)强大的免疫刺激活性活动所必需的物质。脂质A是脂多糖的疏水结构域，有助于将脂多糖锚定在细菌的质膜上。它具有免疫活性，是可由免疫系统识别的脂多糖的重要组成部分。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000486028
0000486028
0000406510
0000406510
0000367391

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J G Schiller et al.
Infection and immunity, 14(2), 586-589 (1976-08-01)
The lipid A precipitate obtained by partial hydrolysis in 1% acetic acid of the glycolipid of a mutant strain of Salmonella minnesota (rough strain R595) was separated into a number of components by thin-layer chromatography. When tested as bovine serum
S Eperon et al.
Journal of immunological methods, 207(2), 135-145 (1997-11-22)
The aim of this study was to develop an in vitro test system for pyrogenic substances. Three clones derived from human monocytoid cell lines, which were selected by their high sensitivity to lipopolysaccharide (LPS), were assessed for tumor necrosis factor
Characterization of the effects of endotoxin on macrophage tumor cell killing.
J B Weinberg et al.
Journal of immunology (Baltimore, Md. : 1950), 121(1), 72-80 (1978-07-01)
E E Ribi et al.
Journal of the National Cancer Institute, 55(5), 1253-1257 (1975-11-01)
A transplantable hepatocarcinoma of guinea pigs was used as an experimental model for immunotherapy of cancer. Earlier work showed that complete regression of 6- to 7-day-old tumors could be obtained in about 60% of cases by inoculation of the tumors
N Qureshi et al.
The Journal of biological chemistry, 257(19), 11808-11815 (1982-10-10)
Endotoxin extracted from the heptose-less mutant of Salmonella typhimurium was hydrolyzed in 0.1 N HCl in methanol/water (1:1, v/v) at 100 degrees C to yield lipid A, which was then fractionated on a Sephadex LH-20 column to yield a major
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