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文件

L5399

Sigma-Aldrich

脂质 A，二磷酸酰 来源于大肠杆菌 F583（Rd 突变体）

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别名:
Diphosphoryl Lipid A from E.Coli.
MDL编号:
MFCD00131510
UNSPSC代码:
12352211
PubChem化学物质编号:
24896402
NACRES:
NA.25

生物来源

Escherichia coli (F583 Rd mutant)

质量水平

200

形式

lyophilized powder

运输

ambient

储存温度

2-8°C

SMILES字符串

CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OCC2OC(OP(O)(O)=O)C(NC(=O)CC(O)CCCCCCCCCCC)C(OC(=O)CC(O)CCCCCCCCCCC)C2O)OC(CO)C1OP(O)(O)=O

InChI

1S/C94H178N2O25P2/c1-7-13-19-25-31-37-38-44-50-56-62-68-84(103)115-78(66-60-54-48-42-35-29-23-17-11-5)72-86(105)119-92-88(96-82(101)71-77(65-59-53-47-41-34-28-22-16-10-4)114-83(102)67-61-55-49-43-36-30-24-18-12-6)93(116-79(73-97)90(92)120-122(107,108)109)113-74-80-89(106)91(118-85(104)70-76(99)64-58-52-46-40-33-27-21-15-9-3)87(94(117-80)121-123(110,111)112)95-81(100)69-75(98)63-57-51-45-39-32-26-20-14-8-2/h75-80,87-94,97-99,106H,7-74H2,1-6H3,(H,95,100)(H,96,101)(H2,107,108,109)(H2,110,111,112)

InChI key

GZQKNULLWNGMCW-UHFFFAOYSA-N

一般描述

脂质A是脂多糖(LPS)的基本结构，存在于细菌中。

应用

使用脂质A，来自大肠杆菌F583（Rd突变）的焦磷酰：
  • 研究不同脂类A分子对体外肺周细胞增殖的影响
  • 在THP-1和J774A.1细胞，分别形成新蝶呤和亚硝酸盐
  • 在结合实验中用作脂多糖(LPS)衍生物
  • 刺激脾脏细胞并为toll样受体4 (TLR4)的有丝分裂原刺激

生化/生理作用

脂质A是人体内脂多糖(LPS)强大的免疫刺激活性活动所必需的物质。脂质A是脂多糖的疏水结构域，有助于将脂多糖锚定在细菌的质膜上。它具有免疫活性，是可由免疫系统识别的脂多糖的重要组成部分。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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C B Louise et al.
Infection and immunity, 60(4), 1536-1543 (1992-04-01)
This study explores the in vitro relationship between Shiga toxin-producing Shigella spp. and Escherichia coli and the development of vascular complications in humans following bacillary dysentery. We propose that lipopolysaccharide (LPS; endotoxin) may combine with Shiga toxin to facilitate vascular
E E Ribi et al.
Cancer research, 39(11), 4756-4759 (1979-11-01)
We described elsewhere that the synergistic antitumor activity of endotoxic extracts from Re mutants of gram-negative bacteria and trehalose mycolate against guinea pig syngeneic line 10 tumor was abrogated after peptide substances accompanying these extracts had been removed. This activity
Activation of complement by endotoxin.
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A Carlsson et al.
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Attacin is a 20 kDa antibacterial protein, originally isolated from the immune haemolymph of Hyalophora cecropia. It has been demonstrated previously that attacin causes increased permeability of the outer membrane of Escherichia coli and inhibition of outer-membrane protein synthesis at
Progress in the synthesis and biological evaluation of lipid A and its derivatives
Gao J and Guo Z
Medicinal Research Reviews, 38(2), 556-601 (2018)
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