所有图片(3)
About This Item
经验公式（希尔记法）:
C11H16N2O5
CAS号:
分子量:
256.26
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
推荐产品
生物来源
synthetic (organic)
质量水平
方案
≥95% (HPLC)
表单
powder
溶解性
water: 50 mg/mL, clear, colorless to yellow
储存温度
−20°C
SMILES字符串
CCC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O
InChI
1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)
InChI key
XACKNLSZYYIACO-UHFFFAOYSA-N
生化/生理作用
5-Ethyl-2′-deoxyuridine (EUdR) is used as a 5-fluorouracil (FU) modulator. EtdUrd may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels.
5-Ethyl-2′-deoxyuridine is an analog of pyrimidine, uridine. It is an effective antiviral agent and inhibits cell division in leukemic tumor cells. 5-Ethyl-2′-deoxyuridine interacts with 2′-deoxycytidine phosphate (dCTP) biosynthesis pathway to elicit antiproliferative effects.
联系
Homolog of thymidine
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
R Kumar et al.
Archiv der Pharmazie, 330(8), 259-263 (1997-08-01)
A group of 5-ethyl-5-halo-6-alkoxy (or azido)-5,6-dihydro-2'-deoxyuridines, which differ in configuration at the C-5 and C-6 positions, were synthesized by the regiospecific addition of XR (X = I, Br, Cl; R = alkoxyl, azido) to the 5,6-olefinic bond of 5-ethyl-2'-deoxyuridine (EDU).
5-Ethyl-2?-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil
Kralovanszky J, et al.
Journal of Cancer Research and Clinical Oncology, 125(12), 675-684 (1999)
Modulation of 5-fluorouracil by 5-ethyl-2'-deoxyuridine on cell lines expressing different dihydropyrimidine dehydrogenase activities.
Katona C, Timar F, Jeney A, et al.
Anti-Cancer Drug Design, 10, 561-567 (1999)
P S Imperia et al.
Antiviral research, 9(4), 263-272 (1988-07-01)
Using an in vitro system we measured the corneal epithelial cytotoxicity and the antiviral activity of the antiviral agents idoxuridine (IDU), trifluridine (TFT), ethyldeoxyuridine (EDU), and (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU). Confluent rabbit corneal epithelial cell cultures were established, and the antiviral agents
Synthesis and antiviral activity of acyclic derivatives of 5-ethyl-2'-deoxyuridine.
K Keppeler et al.
Archiv der Pharmazie, 319(4), 360-365 (1986-04-01)
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