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Merck
CN

D7400

Sigma-Aldrich

2'-脱氧腺苷 一水合物

≥99%

别名:

9-(2-脱氧-β- D -呋喃核糖基)腺嘌呤, 腺嘌呤脱氧核苷

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About This Item

经验公式(希尔记法):
C10H13N5O3 · H2O
CAS号:
分子量:
269.26
Beilstein:
91015
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51

生物来源

synthetic (organic)

质量水平

方案

≥99%

表单

powder

溶解性

water: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow

储存温度

2-8°C

SMILES字符串

[H]O[H].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3

InChI

1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1

InChI key

OLXZPDWKRNYJJZ-RRKCRQDMSA-N

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应用

2′-脱氧腺苷一水合物用于:
  • 作为核苷补充品成分
  • 作为标准品,估算增殖油棕胚性悬浮液中的DNA总甲基化率
  • 逆转无菌α基序(SAM)和含组氨酸-天冬氨酸(HD)结构域的蛋白(SAMHD1)
  • 抑制人类免疫缺陷病毒(HIV-1)和乙型肝炎病毒(HBV)

生化/生理作用

2′-脱氧腺苷(2′-dAdo),是脱氧核糖核苷,在能量应激的情况下可能被某些细胞用作能源,影响 cAMP的水平。 2′-dAdo 用于腺苷类似物在各种生物过程中功能的比较研究。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Sonya M Schuh et al.
Biology of reproduction, 77(6), 960-969 (2007-09-01)
Activation of rapid motility apparently is one of the first steps of sperm capacitation and can be studied in vitro. Previously we found that 2-chloro-2'-deoxyadenosine or the catecholamine isoproterenol activates mouse sperm motility in vitro via a pathway mediated by
M Nakamura et al.
The Journal of biological chemistry, 257(23), 13945-13950 (1982-12-10)
Regulation of glucose metabolism in glycolysis by round spermatids was studied. Assay of activities of 11 glycolytic enzymes in cell-free spermatid extracts showed that hexokinase, phosphofructokinase, and glyceraldehyde-3-phosphate dehydrogenase had the lowest activities. When the cells were incubated with glucose
O Magnus et al.
International journal of fertility, 38(2), 123-128 (1993-03-01)
To find differences in effect on sperm motility of agents that increase intracellular cAMP: manganese ion, methyl-isobutyl-xanthine (MIX), 2-deoxyadenosine, glucose, and Mn-MIX and Mn-glucose. Nine men with asthenozoospermia vs. fertile donors. Sperm was washed in Hepes-buffered saline, motility tested by
Don E Farthing et al.
Scientific reports, 7(1), 4043-4043 (2017-06-24)
Deuterated water (
SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-kappaB Activation
Kim ET, et al.
Testing, 28(2), 434-448 (2019)

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