所有图片(6)

文件

C8667

胆固醇

Name: 胆固醇
Brand: SIGMA

Sigma Grade, ≥99%

别名:

3β-羟基-5-胆甾烯, 5-胆甾烯-3β-醇

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所有图片(6)

About This Item

经验公式（希尔记法）:

C₂₇H₄₆O

CAS号:

57-88-5

分子量:

386.65

Beilstein:

1915888

EC 号:

200-353-2

MDL编号:

MFCD00003646

UNSPSC代码:

12352111

eCl@ss:

39023139

PubChem化学物质编号:

24893094

NACRES:

NA.77

生物来源

sheep wool

质量水平

200

等级

Sigma Grade

检测方案

≥99%

形式

powder

bp

360 °C (lit.)

mp

147-149 °C (lit.)

溶解性

water: soluble 0.00003 g/L at 20 °C

密度

1.067 g/mL at 25 °C (lit.)

运输

ambient

储存温度

−20°C

SMILES字符串

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

HVYWMOMLDIMFJA-DPAQBDIFSA-N

基因信息

human ... POLA1(5422) , TOP2A(7153)
rat ... Ar(24208) , Polb(29240)

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应用

用于色谱的标准品

胆固醇用于制备免疫刺激复合物以增强细胞和体液反应。它被掺入动物饲料中以研究富含胆固醇饮食的影响。

生化/生理作用

胆固醇是一种占到细胞膜结构成分约20-25％的脂质。它决定了膜的流动性和渗透性，使其可透过水而不是离子和质子。胆固醇还可调节质膜上存在的转运蛋白和信号蛋白的功能。胆固醇合成的主要部位是小肠和肝脏。

所有生物膜的主要成分；总脑脂质中约25%为胆固醇。

制备说明

胆固醇一水合物在热酒精中可产生透明无色至淡黄色的溶液。它还可溶于丙酮、二恶烷、乙酸乙酯、苯、石油醚、油、脂肪和胆盐的水溶液中。溶液应当避光保存。

通常也和此产品一起购买

产品编号

说明

价格

700041P

胆固醇d7, Avanti Research^™ - A Croda Brand

840034C

16:0-18:1 PS (POPS), Avanti Research^™ - A Croda Brand

840455P

16:0 PG, Avanti Research^™ - A Croda Brand

850345P

14:0 PC (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine, powder

850355P

16:0 PC（DPPC）, Avanti Research^™ - A Croda Brand

850365P

18:0 PC (DSPC), Avanti Research^™ - A Croda Brand

850375C

18:1 (Δ9-Cis) PC (DOPC), Avanti Research^™ - A Croda Brand

850375P

18:1（Δ9-顺式）PC (DOPC), Avanti Research^™ - A Croda Brand

850457C

16:0-18:1 PC, Avanti Research^™ - A Croda Brand

850457P

16:0-18:1 PC, Avanti Research^™ - A Croda Brand

850725P

18:1（Δ9-顺式）PE (DOPE), Avanti Research^™ - A Croda Brand

100600P

大肠杆菌提取物极性, Avanti Research^™ - A Croda Brand

880120P

18:0 PEG2000 PE, Avanti Research^™ - A Croda Brand

610017

注射器（1000μL), Avanti Research^™ - A Croda Brand

610000

挤出器套件，带支架/加热块, Avanti Research^™ - A Croda Brand

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Effects of probiotic bacteria, isoflavones and simvastatin on lipid profile and atherosclerosis in cholesterol-fed rabbits: a randomized double-blind study

Cavallini DC et al

Lipids in Health and Disease, 8, doi: 10-doi: 10 (2009)

Effects of 2 or 5 consecutive exercise days on adipocyte area and lipid parameters in Wistar rats

Guerra RL et al

Lipids in Health and Disease, 6, doi: 10-doi: 10 (2007)

The combined CTA1-DD/ISCOM adjuvant vector promotes priming of mucosal and systemic immunity to incorporated antigens by specific targeting of B cells.

Anja Helgeby et al.

Journal of immunology (Baltimore, Md. : 1950), 176(6), 3697-3706 (2006-03-07)

The cholera toxin A1 (CTA1)-DD/QuilA-containing, immune-stimulating complex (ISCOM) vector is a rationally designed mucosal adjuvant that greatly potentiates humoral and cellular immune responses. It was developed to incorporate the distinctive properties of either adjuvant alone in a combination that exerted

Mycobacterium tuberculosis releases an antacid that remodels phagosomes.

Jeffrey Buter et al.

Nature chemical biology, 15(9), 889-899 (2019-08-21)

Mycobacterium tuberculosis (Mtb) is the world's most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene nucleoside of unknown function. In the present study 1-TbAd has been shown to be a naturally evolved phagolysosome disruptor. 1-TbAd

Comparative study of fatty acid and sterol profiles for the investigation of potential milk fat adulteration.

M A Nurseitova et al.

Journal of dairy science, 102(9), 7723-7733 (2019-07-01)

Milk fat adulteration is a common issue in Central Asia. To assess the current situation in the commercial milk market, 17 milk samples were checked for fatty acid (FA) and sterol profiles to detect potential adulteration using multivariate analysis. Analysis

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胆固醇生物合成

胆固醇的生物合成通常发生在肝细胞的内质网中，并以乙酰辅酶A开始，乙酰辅酶A主要来源于线粒体中的氧化反应。乙酰辅酶A和乙酰乙酰辅酶A由HMG-辅酶A合成酶转化为3-羟基-3-甲基戊二酰辅酶A（HMG-辅酶A）。

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胆固醇