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Merck
CN

741884

Sigma-Aldrich

Poly(2-ethyl-2-oxazoline)

average Mn 20,000, PDI <1.4

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About This Item

UNSPSC代码:
12162002
NACRES:
NA.23

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表单

solid

质量水平

分子量

average Mn 20,000

mp

>300 °C

PDI

<1.4

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此商品
A3144212814219517
form

solid

form

powder

form

-

form

solid

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

grade

p.a.

grade

-

grade

-

grade

-

technique(s)

UV/Vis spectroscopy: suitable

technique(s)

-

technique(s)

-

technique(s)

-

应用

This Poly(2-ethyl-2-oxazoline) polymer is amorphous and water soluble with good temperature stability. Jordan and coworkers showed biocompatibility, no accumulation in tissue, and rapid clearance from the bloodstream1. End-group modified poly(2-ethyl-2-oxazoline)s have been conjugated to peptides2, and were shown as versatile alternatives to poly(ethylene glycol) (PEG) for both protein and small drug conjugation3.

Potential substitute for poly(vinyl alcohol) and poly(vinyl pyrrolidone). Sometimes it is used as an adhesion promoter in coatings. This is also sometimes used in heat sealing and remoistenable hot-melt adhesives. N-propionyl substituted linear polyethylenimine

特点和优势

Nonionic, water-soluble thermoplastic. Better heat stability than poly(vinyl alcohol). Good melt flow, shear stability and Newtonian characteristics. Water is a room temperature Theta solvent.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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F. C. Gaertner, R. Luxenhofer, B. Blechert, R. Jordan, M. Essler
J. Controlled Release, 119, 291-300 (2007)
A. Mero, G. Pasut, L. D. Via, M.W. M. Fijten, et al.
J. Controlled Release, 125, 87-95 (2008)
R. Luxenhofer, M. Lopez-Garcia, A. Frank, H. Kessler, R. Jordan
Polym. Mater. Sci. Eng., 95, 283-284 (2006)
Yung-Chu Chen et al.
Journal of biomedical materials research. Part A, 100(5), 1279-1292 (2012-03-01)
The multifunctional nanoparticles constructed from triphenylamine-poly(lactide-co-glycolide)-poly(ethyleneglycol)-poly(lactide-co-glycolide) (TPA-PEP) and folate-poly(2-ethyl-2oxazoline)-poly(D,L-lactide) (folate-PEOz-PLA) were developed in this study. Iron oxide nanoparticles (IOP) and paclitaxel (PTX) were coencapsulated in the nanoparticles with diameter less than 200 nm. The drug-loaded nanoparticles emit fluorescence peak at
Chau-Hui Wang et al.
Journal of controlled release : official journal of the Controlled Release Society, 108(1), 140-149 (2005-09-27)
Polymeric micelles based on poly(L-lactide)-b-poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PLLA-PEOz-PLLA) ABA triblock copolymers were designed as intracellular drug carriers. The PLLA-PEOz-PLLA micelles adopt a "flower-like" arrangement with A-blocks at the core and a B-block on the shell under neutral condition. The deformation of the

商品

Poly(2-oxazoline)s, synthesized via LCROP, resemble polypeptides and have various applications in polymer chemistry.

PiPrOx-based polymers exhibit diverse stimuli-responsive properties, showcased in recent developments for functional polymer systems.

The introduction of polymers into the biomedical field has opened new avenues in tissue engineering, implant design, biosensing, and drug delivery.

Microparticles in drug delivery: Study on controlling chitosan microparticle size and distribution, exploring encapsulation of BSA and TPP cross-linker.

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