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Merck
CN

372846

Sigma-Aldrich

聚(2-乙基-2-恶唑啉) 5-7 cSt

别名:

聚(2-乙基-2-恶唑啉), PEOX, POx, PetOx, 聚 2-乙基恶唑啉, 聚乙氧基唑啉

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About This Item

线性分子式:
[-N(COC2H5)CH2CH2-]n
CAS号:
MDL编号:
UNSPSC代码:
12162002
PubChem化学物质编号:
NACRES:
NA.23

表单

solid

质量水平

分子量

average Mw ~50,000

折射率

n20/D 1.52

粘度

5-7 cSt, 10 % in water(100 °F)

转变温度

softening point 110-120 °C (Vicat, ASTM D 1525-82)
Tg 69-71 °C

密度

1.14 g/mL at 25 °C (lit.)

PDI

3‑4

InChI

1S/C5H9NO/c1-2-5-6-3-4-7-5/h2-4H2,1H3

InChI key

NYEZZYQZRQDLEH-UHFFFAOYSA-N

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应用

这种聚(2-乙基-2-恶唑啉)聚合物是无定形和水溶性的,具有良好的温度稳定性。Jordan 及其同事证明了生物相容性,其在组织中无蓄积,并从血流中快速清除 。末端基团修饰的聚(2-乙基-2-恶唑啉)已与肽偶联 ,并被证明可以替代聚乙二醇 (PEG) 用于蛋白质和小分子药物的偶联 。

聚(乙烯醇)和聚(乙烯基吡咯烷酮)的潜在替代品。涂料中的粘合促进剂。热封和可再湿润的热熔胶

特点和优势

非离子型水溶性热塑性塑料。具有比聚乙烯醇更优越的热稳定性。具有良好的熔体流动性、剪切稳定性和牛顿特性。水是室温 θ 溶剂。

外形

N-丙酰基取代线性聚乙烯亚胺

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Chau-Hui Wang et al.
Biomacromolecules, 4(6), 1487-1490 (2003-11-11)
A new series of cationic, thermo-sensitive, and biodegradable poly(L-lactide)-poly(2-ethyl-2-oxazoline)-poly(L-lactide) (PLLA-PEOz-PLLA) triblock copolymers were synthesized by ring-opening polymerization. With increasing molecular weight and crystallinity of hydrophobic PLLA blocks, the critical micellization concentrations (CMC) occurred at lower concentration. The PLLA-PEOz-PLLA aqueous solution
I C Kwon et al.
Nature, 354(6351), 291-293 (1991-11-28)
New controlled drug-delivery systems are being explored to overcome the disadvantages of conventional dosage forms. For example, stimulated drug-delivery has been used to overcome the tolerance problems that occur with a constant delivery rate, to mimic the physiological pattern of
Yung-Chu Chen et al.
Journal of biomedical materials research. Part A, 100(5), 1279-1292 (2012-03-01)
The multifunctional nanoparticles constructed from triphenylamine-poly(lactide-co-glycolide)-poly(ethyleneglycol)-poly(lactide-co-glycolide) (TPA-PEP) and folate-poly(2-ethyl-2oxazoline)-poly(D,L-lactide) (folate-PEOz-PLA) were developed in this study. Iron oxide nanoparticles (IOP) and paclitaxel (PTX) were coencapsulated in the nanoparticles with diameter less than 200 nm. The drug-loaded nanoparticles emit fluorescence peak at
Chau-Hui Wang et al.
Journal of controlled release : official journal of the Controlled Release Society, 108(1), 140-149 (2005-09-27)
Polymeric micelles based on poly(L-lactide)-b-poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PLLA-PEOz-PLLA) ABA triblock copolymers were designed as intracellular drug carriers. The PLLA-PEOz-PLLA micelles adopt a "flower-like" arrangement with A-blocks at the core and a B-block on the shell under neutral condition. The deformation of the
S R Winn et al.
Orthodontics & craniofacial research, 8(3), 183-190 (2005-07-19)
Bone repair strategies continue to be developed for alternatives to autografting, allogeneic implants of banked bone, and other bone substitutes. Efforts have included the delivery of potent growth and/or differentiation factors and the use of gene therapy. For bone regeneration

商品

The introduction of polymers into the biomedical field has opened new avenues in tissue engineering, implant design, biosensing, and drug delivery.

We present an article that discusses two applications in particular; first, using these layers as polyelectrolyte membranes to control permeability.

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