所有图片(2)
About This Item
经验公式（希尔记法）:
C18H12O3
CAS号:
分子量:
276.29
MDL编号:
UNSPSC代码:
12352205
PubChem化学物质编号:
NACRES:
NA.25
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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
red
溶解性
DMSO: 1 mg/mL
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
SMILES字符串
Cc1coc2-c3ccc4c(C)cccc4c3C(=O)C(=O)c12
InChI
1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
InChI key
AIGAZQPHXLWMOJ-UHFFFAOYSA-N
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一般描述
Tanshinone I （Tan I）是一种酚类化合物，主要由丹参（Danshen）中分离。它具有松香烷二萜降三萜o-醌结构。Tan I的水溶性较差。
应用
Tanshinone 1 已被用于：
- 测定其对人白血病细胞系和斑马鱼异种肿瘤移植模型的造血作用
- 研究其对两种乳腺癌细胞系（MCF7 和MDA-MB-23）的抗癌作用
- 作为标准品通过高效液相色谱（(HPLC）法定量测定丹参提取物（SME）的生物活性成分
生化/生理作用
中药丹参（Salvia miltiorrhiza）中的菲醌成分。 通过调节粘附分子来调节或预防乳腺癌转移。抗炎症。
研究人员广泛研究了TanshinoneI的抗癌特性。据报道它抑制癌症侵袭、转移和迁移，是强效抗肿瘤剂。它还具有抗菌、神经保护、改善记忆和心血管保护活性。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Xin Liu et al.
Biomaterials, 34(3), 817-830 (2012-11-01)
Tanshinone IIA is a good candidate for treating cerebral ischemia, but its short half-life and poor permeability across the blood-brain-barrier (BBB) limit its curative efficacy. In this study, we successfully developed cationic bovine serum albumin-conjugated tanshinone IIA PEGylated nanoparticles (CBSA-PEG-TIIA-NPs).
Paul Chan et al.
The American journal of Chinese medicine, 40(6), 1307-1319 (2012-12-12)
The injury of endothelial cell is the critical event of vascular disease. In endothelial cell, oxidative stress is regarded as critical to pathogenic factors in endothelial cell injury and apoptosis. Tanshinone IIA is the main effective component of Salvia miltiorrhiza
Xiao Zhang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 595-603 (2013-01-29)
The aim of this study was to develop novel multiple agents loaded poly (D,L-lactide-co-glycolide acid) (PLGA) nanoparticles (NPs) and evaluate their potential for brain delivery via inner ear administration. PLGA NPs loaded with salvianolic acid B (Sal B), tanshinone IIA
Hui Ma et al.
The American journal of Chinese medicine, 41(1), 197-210 (2013-01-23)
Natural product Tanshinone IIA (TanIIA) induces apoptosis and differentiation in hepatocellular carcinoma (HCC) cells, but its clinical use is limited due to poor water solubility and lack of appropriate formulations for drug delivery. In this study, we capsulated TanIIA into
Yan-Ling Li et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(5), 678-682 (2013-06-04)
To study the application of degrading multi-enzymes from Ganoderma lucidum in extracting effective constituents from fibrous roots of Salvia miltiorrhiza. Effective constituents were extracted from fibrous roots by degrading multi-enzymes of wood fiber. The enzymatic parameters were optimized by the
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