C5624
隐丹参酮
≥98% (HPLC)
别名:
1,2,6,7,8,9-六氢-1,6,6-三甲基 - （R） - 菲啰啉（1,2-b）呋喃-10,11-二酮, 丹参酮 C, 隐丹参酮
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关于此项目
经验公式（希尔记法）:
C19H20O3
化学文摘社编号:
分子量:
296.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
隐丹参酮, ≥98% (HPLC)
InChI key
GVKKJJOMQCNPGB-JTQLQIEISA-N
SMILES string
C[C@H]1COC2=C1C(=O)C(=O)c3c4CCCC(C)(C)c4ccc23
InChI
1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -80 to -99°, c = 0.5 in chloroform-d
storage condition
desiccated
protect from light
color
orange-brown
solubility
DMSO: ≥5 mg/mL
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
隐丹参酮是一种从亚洲药用植物丹参的根中分离出的醌类二萜。最新研究表明，该化合物是有效的 STAT3 抑制剂。隐丹参酮通过 JAK2 非依赖性机制快速抑制 STAT3 Tyr705 磷酸化。隐丹参酮通过与单体 STAT3 结合选择性抑制 STAT3 活化的细胞系，随后阻断二聚化并抑制 STAT3 转录调节活性。以前，研究据报道了该化合物通过抑制环加氧酶 II 活性和内皮素-1 的表达来消除炎症。丹参（Danshen）的干根在传统的东方医学中通常用于治疗循环障碍、肝病、冠心病、肝炎和慢性肾衰竭。
隐丹参酮是一种特异性 STAT3 抑制剂。它可以防止 STAT3 二聚化。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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