Quality Level
usage
kit sufficient for 250 reactions
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... BACE1(23621)
Application
该试剂盒包含有效检测BACE1活性所需的全部试剂。其中包含筛选潜在BACE1抑制剂的酶。该检测基于荧光共振能量转移 (FRET) 技术，即在BACE1切割底物后观测增强的荧光信号。
Biochem/physiol Actions
作为一种跨膜蛋白酶，BACE1负责切割淀粉样前体蛋白 (APP) 的β位点来产生β淀粉样肽 (Aβ)。大脑中Aβ积累是阿尔茨海默氏症的主要病因。BACE1是抑制剂药物研发的靶点。
仅试剂盒组分
产品编号
说明
- Fluorescent Assay Buffer 50 mL
- Stop Solution 15 mL
- Substrate (MOCA-SEV-NL-DAEFR-DNP-RR) 500 μL
- Assay Standard 140 μL
- BACE1 (β−Secretase) 300 units 100 μL
存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
常规特殊物品
此项目有
相关内容
Lucas J Gutiérrez et al.
Journal of biomolecular structure & dynamics, 37(1), 229-246 (2018-01-06)
We report in this work new substituted aminopyrimidine derivatives acting as inhibitors of the catalytic site of BACE1. These compounds were obtained from a molecular modeling study. The theoretical and experimental study reported here was carried out in several steps:
Piyoosh Sharma et al.
European journal of medicinal chemistry, 167, 510-524 (2019-02-21)
The multitarget-directed strategy offers an effective and promising paradigm to treat the complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were designed and synthesized as multi-functional inhibitors of acetylcholinesterase (AChE) and
Maricarmen Hernández-Rodríguez et al.
Molecular neurobiology, 57(9), 3979-3988 (2020-07-09)
The increase of amyloid beta (Aβ) release and hyperphosphorylation of Tau protein represents the main events related to Alzheimer's disease (AD). Furthermore, the sporadic type represents the most common form of AD. Therefore, the establishment of a non-transgenic animal model
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| CS0010-1KT | 04061833553053 |