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方案
≥90% (LC/MS-UV)
表单
solid
溶解性
DMSO: 1 mg/mL
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
OC1=CC(O)=C(C(C(O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1
InChI
1S/C21H20O10/c1-8-15(25)17(27)18(28)21(29-8)31-20-16(26)14-12(24)6-11(23)7-13(14)30-19(20)9-2-4-10(22)5-3-9/h2-8,15,17-18,21-25,27-28H,1H3/t8-,15-,17+,18+,21-/m0/s1
InChI key
SOSLMHZOJATCCP-AEIZVZFYSA-N
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一般描述
Afzelin来源于植物的天然产物。黄酮类醇苷Afzelin的主要来源为掌叶榕和香睡莲。
应用
保护DNA、抗氧化、抗炎、吸收紫外线和抗菌活性。Afzelin已用于高效液相色谱法(HPLC)分析,以检测复方蒿提取物中的主要成分。
生化/生理作用
Afzelin是NOS抑制剂和NADPH氧化酶抑制剂,具有抗菌、抗炎、抗凋亡和抗肿瘤活性。Afzelin可作为铜绿假单胞菌相关疾病的有效治疗药物。Afzelin还能促进乳腺癌细胞凋亡,抑制细胞增殖。在小鼠模型中表现出抗哮喘作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Seoung Woo Shin et al.
PloS one, 8(4), e61971-e61971 (2013-04-30)
Ultraviolet (UV) radiation induces DNA damage, oxidative stress, and inflammatory processes in human keratinocytes, resulting in skin inflammation, photoaging, and photocarcinogenesis. Adequate protection of skin against the harmful effects of UV irradiation is essential. Therefore, in this study, we investigated
Agrimoniin, an active ellagitannin from Comarum palustre herb with anti-α-glucosidase and antidiabetic potential in streptozotocin-induced diabetic rats
Kashchenko N, et al.
Molecules (Basel), 22(1), 73-73 (2017)
Sang Yeol Lee et al.
Molecules (Basel, Switzerland), 19(3), 3173-3180 (2014-03-20)
The crude ethyl acetate extract of the leaves of Cornus macrophylla showed antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals. Bioactivity-guided separation led to the isolation of kaempferol 3-O-α-L-rhamnopyranoside (afzelin). The structure was determined based
Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma
Zhou Wenbo and Nie Xiuhong
Molecular Medicine Reports, 12(1) (2015)
Parham Taslimi
Journal of biochemical and molecular toxicology, 34(11), e22566-e22566 (2020-07-03)
Tyrosinase enzyme is a functional oxidase that is extensively divided in nature. It is the main enzyme in melanin synthesis and is also involved in designating the color of mammalian hair and skin. Additionally, it is accountable for the unfavorable
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