推荐产品
生物来源
Salvia miltiorrhiza
方案
≥98% (HPLC)
表单
powder
储存条件
protect from light
颜色
red
溶解性
ethanol: 1 mg/mL, clear, orange to red
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
SMILES字符串
C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O
InChI
1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
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此商品 | B9285 | D5412 | I7125 |
|---|---|---|---|
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| assay ≥99% (HPLC) | assay ≥99% | assay ≥98.5% | assay ≥99% (HPLC) |
| form powder | form powder | form powder | form powder or crystals |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. 2-8°C |
| solubility DMSO: 50 mg/mL, clear, colorless to very faintly yellow | solubility NH4OH: 0.1 M at 20 °C, clear, colorless | solubility water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow | solubility 1 N NH4OH: 50 mg/mL, clear to very slightly hazy, colorless to light yellow |
一般描述
DihydrotanshinoneI (DHTS) is a tanshinone derivative which is a soluble diterpene quinone pigment of danshen.
应用
Dihydrotanshinone I (DHTS) has been used:
- to study its cytocidal effects on chemosensitive ovarian cancer cells with or without platinum-based chemotherapy
- as a treatment to study its inhibitory effects on triple-negative breast cancer cells growth by modulating epithelial-mesenchymal transition (EMT) markers
- as a potential SARS-CoV-2 papain-like protease (PLpro) inhibitor
- as a human antigen R (HuR) inhibitor to study its role in Th17 cell differentiation related to autoimmune neuroinflammation
- as a reference standard to analyze Salvia miltiorrhiza Bunge extract (SME) components using high-performance liquid chromatography(HPLC)
生化/生理作用
Dihydrotanshinone Iis a potent anti-cancer agent with its cytotoxic, apoptosis, cell cycle arresteffects and inhibition of angiogenesis, and metastasis in cancer cells. Italso exerts cardiovascular and cerebrovascular protective effects. DHTS isan anti-inflammatory, anti-ischemia-reperfusion (I/R), anti-allergic,anti-Alzheimer’s disease properties. It is also effective againstdrug-resistant cancer cells.
Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ok Kyu Park et al.
Fitoterapia, 83(8), 1666-1674 (2012-10-02)
We observed neuroprotective effects of five major lipophilic diterpenes derived from Danshen (Radix Salvia miltiorrhiza) extract, such as cryptotanshinone (CTs), dihydrotanshinone I (DTsI), tanshinone I (TsI), tanshinone IIA (TsIIA) and tanshinone IIB (TsIIB), in the hippocampal CA1 region (CA1) against
W D Lee et al.
Nanotechnology, 27(49), 495101-495101 (2016-11-12)
Danshen (Salvia miltiorrhiza), a Chinese medicinal herb, consists of several functional components including tanshinones responsible for prevention of several chronic diseases. This study intends to prepare tanshinone extract and nanoemulsion from danshen and determine their inhibition effect on lung cancer
Sarah R Anthony et al.
Adipocyte, 9(1), 335-345 (2020-07-28)
The goal of this study was to define the functional role of adipocyte-specific expression of the RNA binding protein Human antigen R (HuR). Mice with an adipocyte-specific deletion of HuR (Adipo-HuR-/- ) were generated by crossing HuR floxed (HuRfl/fl )
Jiliang Cao et al.
Journal of chromatographic science, 54(8), 1435-1444 (2016-05-04)
A simple and fast micellar electrokinetic chromatography (MEKC) method using ionic liquids as modifier was established for simultaneous determination of four hydrophobic tanshinones, including dihydrotanshinone I ( 1: ), cryptotanshinone ( 2: ), tanshinone I ( 3: ) and tanshinone
Akanksha Kashyap et al.
Asian Pacific journal of cancer prevention : APJCP, 22(7), 2177-2184 (2021-07-29)
Salvia miltiorrhiza Bunge (Danshen), has been used for its therapeutic value in Traditional Chinese Medicine (TCM), for almost a thousand years. Dihydrotanshinone-I (DHTS) is a lipophilic compound isolated from the plant Salvia miltiorrhiza that has been shown to induce anti-proliferative
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