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P8765

Sigma-Aldrich

吡咯烷二硫代氨基甲酸铵

~99%

别名:

1-吡咯烷二硫代羧酸 铵盐, APDC, PDC, PDTC, 吡咯烷二硫代氨基甲酸铵

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1 KIT
¥5,282.92

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About This Item

线性分子式:
C5H9NS2 · NH3
CAS号:
5108-96-3
分子量:
164.29
Beilstein:
3730472
EC 号:
225-834-4
MDL编号:
MFCD00012720
UNSPSC代码:
12352107
PubChem化学物质编号:
24278658
NACRES:
NA.77

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生物来源

microbial

方案

~99%

表单

(powderor powder with lumps)

mp

153-155 °C (lit.)

溶解性

water: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

储存温度

2-8°C

SMILES字符串

N.SC(=S)N1CCCC1

InChI

1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3

InChI key

MDDIUTVUBYEEEM-UHFFFAOYSA-N

基因信息

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) , RELA(5970)

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I3911

蛋白酶抑制剂混合物，不含动物成分

Protease Inhibitor Cocktail for use in tissue culture media, DMSO solution

P1860

Protease Inhibitor Cocktail

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

200

biological source

bovine lung

biological source

-

biological source

-

biological source

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

一般描述

吡咯烷二硫代甲酸铵盐是一种核因子κB (NF-κB)抑制剂。[1]它作为一种螯合剂，可以从溶液中预浓缩痕量金属。[2]吡咯烷二硫代甲酸铵盐（PDTC）具有抗氧化性质。它能抑制淋巴细胞、神经元和血管内皮细胞的凋亡。[3]

应用

吡咯烷二硫代甲酸铵盐已被用于：
  • 抑制人单核细胞中的核因子κB（NF-κB）动员和TNF（肿瘤坏死因子）产生[4]
  • 降低大鼠的中性粒细胞活性[5]
  • 防止阿霉素（ADR）处理的足细胞的Ca2+内流[6]

消除人脑细胞中microRNA-146a启动子荧光素酶报告基因活性[7]

生化/生理作用

通过抑制 NOS mRNA 的翻译从而阻止一氧化氮合成酶的诱导；引发大鼠平滑肌细胞中的细胞凋亡并抑制白血病 HL-60 细胞中的细胞凋亡。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    BCCM6597
    BCCH2413
    BCCF3413
    BCBW0506
    BCBR8189V

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    如果您需要特殊版本，可通过批号或批次号查找具体证书。

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    1. How does the storage temperature relate to shipping conditions?

      The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

    2. Which document(s) contains shelf-life or expiration date information for a given product?

      If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

    3. How do I get lot-specific information or a Certificate of Analysis?

      The lot specific COA document can be found by entering the lot number above under the "Documents" section.

    4. How do I find price and availability?

      There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

    5. What is the Department of Transportation shipping information for this product?

      Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

    6. How can I prepare a solution of Product P8765, Ammonium pyrrolidinedithiocarbamate?

      Ammonium pyrrolidinedithiocarbamate is soluble in water at a concentration of approximately 50 mg/mL.

    7. What is the solution stability of Product P8765, Ammonium pyrrolidinedithiocarbamate?

      Sigma-Aldrich has not performed a controlled solution stability test on PDTC. However, we have found that aqueous stock solutions are typically stable for at least one month when stored at -20 °C.

    8. What are some functions reported for Product P8765, Ammonium pyrrolidinedithiocarbamate?

      PDTC has been reported to repress vascular cell adhesion molecule-1 (VCAM-1) activation by Interleukin-1β in cultured human umbilical vein endothelial calls. Marui, M., et al., J. Clin. Invest, 92, 1866 (1993).  It inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Sherman, M.P., et al., Biochem. Biophys. Res. Commun. 191, 1301-1308 (1993).  It is an Inhibitor of nuclear factor kappa B., Eberhardt, et al. Biochem. Biophys. Res. Commun. 200, 163 (1994). PDTC at 100  μM, totally inhibited the NF-kappa B response in intact cells. Schreck, R., et al., J. Exp. Med. 175 , 1181-1194 (1992). It activates cAMP-dependent protein kinase (PKA) in a colorectal cancer cell line. Chinery, R., et al., J. Biol. Chem., 272, 30356 - 30361, (1997).

    9. My question is not addressed here, how can I contact Technical Service for assistance?

      Ask a Scientist here.

    An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells
    Lukiw WJ, et al.
    The Journal of Biological Chemistry, 283(46), 31315-31322 (2008)
    Quan Zhou et al.
    Oncogene, 39(7), 1414-1428 (2019-10-30)
    Gastric cancer (GC) is characterized by extensive local invasion, distant metastasis and poor prognosis. In most cases, GC progression is associated with aberrant expression of cytokines or activation of signaling cascades mediated by tumor-stroma interactions. However, the mechanisms by which
    Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells
    Tsai JC, et al.
    The Journal of Biological Chemistry, 271(7), 3667-3670 (1996)
    Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production
    Ye J, et al.
    Experimental Cell Research, 340(2), 315-326 (2016)
    Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage
    Friedrich V, et al.
    Journal of Neuroinflammation, 8(1), 103-103 (2011)
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