I2786
Interleukin-6 human
IL-6, recombinant, expressed in E. coli, Carrier Free
别名:
Interleukin-6 human, B cell stimulating factor (BSF-2), IL-6, IL6, hepatocyte stimulating factor (HSF), interferon b2 (IFNb2), interleukin hybridoma/plasmacytoma-1 (IL-HP1), monocyte derived human B cell growth factor, plasmacytoma growth factor (PCT-GF)
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About This Item
一般描述
Interleukin-6 (IL-6) is a multi-functional 26 kDa protein originally discovered in the medium of RNA-stimulated fibroblastoid cells1. IL-6 appears to be directly
involved in the immune responses that occur after infection and cellular injury, and it may prove to be as important as IL-1 and TNF-a in regulating the acute phase response2,3.
IL-6 is reportedly produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells, and hepatocytes. IL-6 induces multiple effects as indicated by its numerous synonyms4. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes5. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors6.This product is lyophilized from a 0.2 mm-filtered solution of phosphate buffered saline, pH 7.4, containing a stabilizer.
The product was prepared from raw materials verified to be carrier free.
involved in the immune responses that occur after infection and cellular injury, and it may prove to be as important as IL-1 and TNF-a in regulating the acute phase response2,3.
IL-6 is reportedly produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells, and hepatocytes. IL-6 induces multiple effects as indicated by its numerous synonyms4. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes5. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors6.This product is lyophilized from a 0.2 mm-filtered solution of phosphate buffered saline, pH 7.4, containing a stabilizer.
The product was prepared from raw materials verified to be carrier free.
应用
Human interleukin-6 (IL-6) has been used to study the effects of IL-6, along with IL-8 and IL-1β, on the clot structure of healthy blood.
生化/生理作用
IL-6 is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Simultaneous presence of hypercoagulation and increased clot lysis time due to IL-1beta, IL-6 and IL-8
Janette B, et al.
Cytokine (2018)
Interleukin-6: an overview.
J Van Snick
Annual review of immunology, 8, 253-278 (1990-01-01)
A new interleukin with pleiotropic activities.
T Kishimoto et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 9(1), 11-15 (1988-07-01)
Tadamitsu Kishimoto
Clinical reviews in allergy & immunology, 28(3), 177-186 (2005-09-01)
In the late 1960s, the essential role of T-cells in antibody production was reported. This suggested to us that certain molecules should be released from T-cells for the stimulation of B-cells. We discovered activities in the culture supernatant of T-cells
J Van Snick et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(24), 9679-9683 (1986-12-01)
A T-cell-derived lymphokine was identified by its ability to support the growth of a subset of B-cell hybridomas. Hybrids that failed to survive in the absence of this molecule represented a major proportion of rat-mouse hybridomas but were very rare
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