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一般描述
The IL6 (interleukin-6) gene is mapped to human chromosome 7p15.3. All the members of IL6 family have membrane glycoprotein gp130 as a common receptor. IL6 (interleukin-6) induces B-cell differentiation and is a primary regulator of inflammation.
应用
Interleukin-6 human has been used to check its role in breast cancer metastasis. It has also been used for evaluating its role in D5HS tumor sphere formation.
生化/生理作用
IL6 regulates tumor proliferation and inhibits apoptosis. It contributes to the disease progression of coronary artery disease.
白细胞介素-6 (IL-6) 是最初在双链 RNA 刺激的细胞培养基中发现的一种多功能蛋白。IL-6 似乎直接参与了感染和损伤后发生的反应，并可能证明在调节急性期反应方面与 IL-1 和 TNF-α 同样重要。据报道，IL-6 由成纤维细胞、活化的 T 细胞、活化的单核细胞或巨噬细胞以及内皮细胞产生。作用于多种细胞，包括成纤维细胞、髓系祖细胞、T 细胞、B 细胞和肝细胞。如许多同义词所示，IL-6 诱导多种效应：浆细胞瘤生长因子 (PCT-GF)、干扰素-β-2（IFN-β 2 ）、单核细胞来源的人 B 细胞生长因子、B 细胞刺激因子 (BSF-2)、肝细胞刺激因子 (HSF)、白细胞介素杂交瘤/浆细胞瘤-1 (IL-HP1)。此外，IL-6 似乎在 T 淋巴细胞增殖中与 IL-2 相互作用。IL-6 还可增强 IL-3 对多潜能造血祖细胞的增殖作用。
制备说明
Human IL-6, expressed in human 293 cells, is a glycosylated monomer with an apparent molecular mass of 26-30 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
分析说明
The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The pro-and anti-inflammatory properties of the cytokine interleukin-6
Scheller J, et al.
Biochimica et Biophysica Acta, 1813(5), 878-888 (2011)
Generation of Prostate Tumor-initiating Cells is Associated with Elevation of Reactive Oxygen Species and IL6/STAT3 Signaling
Qu Y, et al.
Cancer Research (2013)
Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells
Castellana B, et al.
Oncotarget, 6(35), 38239-38239 (2015)
Donghong Chen et al.
Respiratory research, 22(1), 280-280 (2021-10-30)
IL-35 subunit EBI3 is up-regulated in pulmonary fibrosis tissues. In this study, we investigated the pathological role of EBI3 in pulmonary fibrosis and dissected the underlying molecular mechanism. Bleomycin-induced pulmonary fibrosis mouse model was established, and samples were performed gene
Abhilasha Srivastava et al.
Frontiers in oncology, 11, 811941-811941 (2022-02-08)
Hepatocellular carcinoma (HCC) is often associated with an inflammatory setting. A plethora of cytokines are secreted in this milieu, actively contributing to the progression of the disease; however, the extent of cytokine interaction and how it contributes to HCC development
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