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H7890

Sigma-Aldrich

L-高丝氨酸内酯 盐酸盐

suitable for ligand binding assays

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50 ML
¥1,251.31
250 ML
¥3,005.35

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国内现货，预计发货时间2025年4月23日详情

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50 ML
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About This Item

经验公式（希尔记法）:
C4H7NO2 · HCl
CAS号:
2185-02-6
分子量:
137.56
MDL编号:
MFCD00058172
UNSPSC代码:
12352209
PubChem化学物质编号:
24895811
NACRES:
NA.26

¥1,251.31

国内现货，预计发货时间2025年4月23日详情

获取大包装报价

产品名称

L-高丝氨酸内酯 盐酸盐,

表单

powder

质量水平

200

技术

ligand binding assay: suitable

颜色

white

储存温度

−20°C

SMILES字符串

Cl.N[C@H]1CCOC1=O

InChI

1S/C4H7NO2.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1

InChI key

XBKCXPRYTLOQKS-DFWYDOINSA-N

一般描述

L-高丝氨酸内酯（HSL），也称为酰化-HSL，由高丝氨酸内酯环和脂肪酰基侧组成。[1] 细菌中的酰基-HSL水平取决于底物和酰化-高丝氨酸内酯合酶的可用性。[2]

应用

L-高丝氨酸内酯盐酸盐已被用作动脉平滑肌收缩的抑制剂。[3]

生化/生理作用

L-高丝氨酸内酯抑制能够减少毒力因子并阻止炎症和组织损伤。[1] 在铜绿假单胞菌（Pseudomonas aeruginosa）中，它能够控制毒力因子产生和生物膜形成。在根癌农杆菌（ Agrobacterium tumefaciens）中，它是接合转移的必需成分。[4]
酰化L-高丝氨酸内酯被用于研究细菌群体感应信号传导机制。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    SLCG7532
    SLCC4644
    SLCB0222
    SLBS7901
    SLBS6943

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    Nathan A Ahlgren et al.
    Proceedings of the National Academy of Sciences of the United States of America, 108(17), 7183-7188 (2011-04-08)
    Many Proteobacteria possess LuxI-LuxR-type quorum-sensing systems that produce and detect fatty acyl-homoserine lactone (HSL) signals. The photoheterotroph Rhodopseudomonas palustris is unusual in that it produces and detects an aryl-HSL, p-coumaroyl-HSL, and signal production requires an exogenous source of p-coumarate. A
    Inhibiting N-acyl-homoserine lactone synthesis and quenching Pseudomonas quinolone quorum sensing to attenuate virulence
    Chan KG, et al.
    Frontiers in Microbiology, 6, 1173-1173 (2015)
    The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-l-homoserine lactone, inhibits porcine arterial smooth muscle contraction
    Lawrence RN, et al.
    British Journal of Pharmacology, 128(4), 845-848 (1999)
    Long-chain acyl-homoserine lactone quorum-sensing regulation of Rhodobacter capsulatus gene transfer agent production
    Schaefer AL, et al.
    Journal of Bacteriology, 184(23), 6515-6521 (2002)
    Defining the structure and function of acyl-homoserine lactone autoinducers
    Churchill MEA, et al.
    Methods in Molecular Biology, 692(23), 159-171 (2011)
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