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Merck
CN

459224

Sigma-Aldrich

(S)-α-氨基-γ-丁内酯 盐酸盐

97%

别名:

L-高丝氨酸内酯 盐酸盐, HSI

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About This Item

经验公式(希尔记法):
C4H7NO2 · HCl
CAS号:
分子量:
137.56
Beilstein:
3562187
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.22

质量水平

方案

97%

表单

powder or crystals

旋光性

[α]20/D −27.8°, c = 1 in H2O

mp

210-220 °C (dec.) (lit.)

应用

peptide synthesis

SMILES字符串

Cl.N[C@H]1CCOC1=O

InChI

1S/C4H7NO2.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1

InChI key

XBKCXPRYTLOQKS-DFWYDOINSA-N

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应用

(S)-α-氨基-γ-丁内酯盐酸盐可用于:
  • 作为制备氨基酮醇和β-氨基酸的前体。
  • 通过与取代2-氯-N-苯乙酰胺和不同卤化物反应,制备N-酰化高丝氨酸内酯 (AHL) 类似物。
  • 作为合成L-discadenine的原料。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Design, synthesis and antibacterial evaluation of novel AHL analogues
Ren J, et al.
Bioorganic & Medicinal Chemistry Letters, 23(14), 4154-4156 (2013)
Natural products from social amoebae
Barnett R and Stallforth P
Chemistry?A European Journal , 24(17), 4202-4214 (2018)
Reaction of (S)-homoserine lactone with Grignard reagents: synthesis of amino-keto-alcohols and β-amino acid derivatives
Gundogdu O, et al.
Tetrahedron Asymmetry, 28(9), 1163-1168 (2017)
L R Brunham et al.
The pharmacogenomics journal, 14(6), 555-563 (2014-05-28)
Differences in the frequency of pharmacogenomic variants may influence inter-population variability in drug efficacy and risk of adverse drug reactions (ADRs). We investigated the diversity of ∼ 4500 genetic variants in key drug-biotransformation and -response genes among three South East
Fiorela Nievas et al.
Sensors (Basel, Switzerland), 12(3), 2851-2873 (2012-06-28)
Bacteria of the genus Bradyrhizobium are able to establish a symbiotic relationship with peanut (Arachis hypogaea) root cells and to fix atmospheric nitrogen by converting it to nitrogenous compounds. Quorum sensing (QS) is a cell-cell communication mechanism employed by a

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