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安全信息

G7516

Sigma-Aldrich

γ-球蛋白 来源于牛血液

≥97% (agarose gel electrophoresis)

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别名:
牛 γ-球蛋白
CAS号:
EC 号:
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

bovine blood

质量水平

检测方案

≥97% (agarose gel electrophoresis)

形式

powder

组成

NaCl, ≤5%

溶解性

0.9% NaCl: soluble 50 mg/mL

储存温度

−20°C

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一般描述

牛丙种球蛋白(BGG)是奶牛和其他牛类免疫系统的重要组成部分。BGG 存在于牛的血液中,主要用于生产疫苗、血清和诊断试剂等医疗制品。BGG 还可用于治疗乙肝等疾病,以及增强人类和其他动物的免疫力。
The γG globulins of bovine serum are categorized by anion exchange chromatography, immunoelectrophoresis, zone electrophoresis, ultracentrifugation, and analysis of the products of papain digestion. They have properties similar to analogous components of human serum. This was determined by the methods such as: gel filtration, immunoelectrophoresis, anion exchange chromatography, ultracentrifugation, and reduction with mercaptoethanol. Fast and slow γG globulins were classified on the basis of differences in electrophoretic migration rates, chromatographic elution positions, and biological activities (complement fixation). Bovine γA was conditionally found in immunoelectrophoretic analyses of serum and chromatographic fractions.

应用

γ-globulin has been used as an immunological challenge in studies of mechanisms of immunotolerance.
Bovine γ-globulins were used to study the constituents and pH changes in protein rich hyaluronan solution affecting the bio-tribological properties of artificial articular joints. It is also used to determine immunoglobulin G in bovine colostrum and milk by direct biosensor SPR-immunoassay.
Bovine γ-globulin was used in rapid screening for monensin residues in poultry plasma by a dry reagent dissociation enhanced lanthanide fluoroimmunoassay. It was also tested for the effects of solution properties on solute and permeate flux in bovine serum albumin-IgG ultrafiltration.
牛γ-球蛋白已被用作免疫耐受机制研究中的一种免疫应激。

制备说明

Prepared from plasma

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

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Liyu He et al.
American journal of nephrology, 43(3), 179-194 (2016-04-14)
Immunoglobulin (Ig) A nephropathy (IgAN) is the xFB01;nding of immune deposits predominantly containing polymeric IgA in the glomerular mesangium on renal biopsy. Increasing evidence suggested that retinoic acid (RA) signaling selectively induces IgA isotype switching and basic leucine zipper transcription
R G Nel et al.
Biotechnology progress, 10(5), 539-542 (1994-09-01)
It has been observed that bovine serum albumin (BSA, 69,000 Da) exhibits high rejection in a pH 7.4, 0.15 M NaCl solution containing low concentrations of immuno-gamma-globulins (IgG, 155,000 Da). Although it is apparent that this phenomenon is likely due
S R Crooks et al.
The Analyst, 123(12), 2493-2496 (1999-08-06)
Monensin, a carboxylic acid ionophore, is commonly fed to poultry to control coccidiosis. A method for rapid analysis of unextracted poultry plasma samples has been developed based on a novel immunoassay format: one-step all-in-one dry reagent time resolved fluorimetry. All
Helen Ludlow et al.
Journal of immunological methods, 329(1-2), 102-111 (2007-11-10)
Inhibin B has emerged as a clinically useful analyte for studies of reproductive function in both men and women. The antibody to the betaB subunit (C5) used in current commercially available assays (DSL and OBI) was raised in this laboratory
T Kitano et al.
Journal of biomechanics, 34(8), 1031-1037 (2001-07-13)
The relationship between the coefficient of friction and pH value or protein constituents of lubricating fluid, together with viscosity, were studied within a bearing surface model for artificial joint, ultra-high molecular weight polyethylene (UHMWPE) against stainless steel (SUS), using a

实验方案

Guidelines for various bioassays on the MultiScreen system, which makes it possible to carry out an assay from sample incubation to scintillation counting in a 96-well plate.

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