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安全信息

G5009

Sigma-Aldrich

γ-球蛋白 来源于牛血液

≥99% (agarose gel electrophoresis)

别名:

牛 γ-球蛋白

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About This Item

CAS号:
EC 号:
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

bovine blood

质量水平

检测方案

≥99% (agarose gel electrophoresis)

形式

powder

组成

NaCl, ≤4%

技术

enzyme immunoassay: suitable

溶解性

0.9% NaCl: soluble 25 mg/mL

储存温度

−20°C

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一般描述

牛丙种球蛋白(BGG)是奶牛和其他牛类免疫系统的重要组成部分。BGG 存在于牛的血液中,主要用于生产疫苗、血清和诊断试剂等医疗制品。BGG 还可用于治疗乙肝等疾病,以及增强人类和其他动物的免疫力。

应用

牛γ-球蛋白已被用于研究富含蛋白质的透明质酸溶液的成分和pH变化,而这些会影响到人工关节的生物学特性。它也可通过直接生物传感器SPR免疫检测测定牛初乳和牛奶中的免疫球蛋白G。
牛γ-球蛋白已被用作免疫耐受机制研究中的一种免疫应激。

生化/生理作用

牛血清的γ-G球蛋白可通过阴离子交换色谱、免疫电泳、区域电泳、超速离心和木瓜蛋白酶消化产物分析而进行分类。它们具有与人血清相似成分类似的属性。这是通过以下方法确定的:凝胶过滤、免疫电泳、阴离子交换色谱、超速离心和巯基乙醇还原。快和慢γ-G球蛋白是根据电泳迁移率、色谱洗脱位置以及生物学活性(补体固定)差异而进行分类的。牛γ-A已被有条件的发现于血清和色谱部分的免疫电泳分析中。

制备说明

由 Cohn 组分 II、III 制备

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the molecular weight of Product G5009, γ-Globulins from bovine blood?

    The molecular weight of 150,000 is based on 2 heavy chains (55,000 each) and 2 light chains (20,000 each).

  4. What is the class of immunoglobulins in Product G5009, γ-Globulins from bovine blood?

    The gamma-globulin is a mixture of IgG (80%), IgM (10%), and IgA (<10%).

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Rui Fang et al.
eLife, 11 (2022-01-21)
The ring-like ATPase complexes in the AAA+ family perform diverse cellular functions that require coordination between the conformational transitions of their individual ATPase subunits (Erzberger and Berger, 2006; Puchades et al., 2020). How the energy from ATP hydrolysis is captured
Harvey E Indyk et al.
Journal of AOAC International, 86(2), 386-393 (2003-05-02)
An automated biosensor surface-plasmon resonance-based assay was developed for the determination of immunoglobulin G (IgG) in bovine milk and colostrum with either goat or rabbit antibovine IgG or protein G used as detecting molecule. The method is configured as a
Marc-Olivier Montjovent et al.
Bioanalysis, 9(18), 1385-1393 (2017-09-29)
Recombinant glycoprotein produced in nonhuman mammalian cell lines can be modified with the immunogenic nonhuman sialic N-glycolylneuraminic acid (Neu5Gc). We describe here a validated method for detection of antidrug antibodies against both protein and Neu5Gc-containing glycan epitopes. An electrochemiluminescent method
T Kitano et al.
Journal of biomechanics, 34(8), 1031-1037 (2001-07-13)
The relationship between the coefficient of friction and pH value or protein constituents of lubricating fluid, together with viscosity, were studied within a bearing surface model for artificial joint, ultra-high molecular weight polyethylene (UHMWPE) against stainless steel (SUS), using a
S M Moreira et al.
Ecotoxicology and environmental safety, 73(5), 893-899 (2010-04-30)
This study proposes short-term sublethal assays for the tropics using the fish Poecilia reticulata. Assays were evaluated under realistic exposure scenarios by simulating a runoff over an agricultural area sprayed with deltamethrin (Decis). In situ assays were performed inside microcosms

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