生物来源
bovine thyroid
质量水平
检测方案
≥90% (agarose gel electrophoresis)
形式
powder
分子量
~670 kDa
组成
Iodine, ≥0.20%
氮含量分析
13.0-16.0% total
灰分
≤4%
溶解性
H2O: 20 mg/mL
UniProt登记号
储存温度
−20°C
基因信息
cow ... TG(280706)
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应用
牛甲状腺球蛋白可刺激大鼠甲状腺滤泡细胞以及原代猪甲状腺上皮细胞的增殖。这种效应是通过 PI3K 信号传导介导的。
通常用作生产抗体的载体蛋白。其优点在于大量的酪氨酸残基可用于重氮反应进行偶联。
生化/生理作用
储存在甲状腺中的含碘蛋白质。当甲状腺受到来自垂体的促甲状腺激素（TSH） 的刺激时，转化为循环甲状腺素。因为其表达是甲状腺所独有的，它是甲状腺消融治疗后甲状腺癌复发或转移的敏感指标。
牛甲状腺球蛋白是一种大的四聚体糖蛋白，由甲状腺产生，是甲状腺激素的前体。其尺寸大且在正常条件下不存在于血浆中，这使其具有很强的免疫原性，并降低了在免疫测定中这种载体蛋白的抗体与血浆蛋白发生交叉反应的机会。半抗原可以通过附近的仲胺与甲状腺球蛋白偶联。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
Mahsa Hadidi et al.
Biotechnology progress, 32(6), 1531-1538 (2016-10-22)
Charged polysaccharides are used in the food industry, as cosmetics, and as vaccines. The viscosity, thermodynamics, and hydrodynamic properties of these charged polysaccharides are known to be strongly dependent on the solution ionic strength because of both inter- and intramolecular
N Murat Karabacak et al.
Molecular & cellular proteomics : MCP, 8(4), 846-856 (2008-12-17)
Top-down and bottom-up mass spectrometry methods can generate gas phase fragments and use these to identify proteins. Top-down methods, in addition, can provide the mass of the protein itself and therefore additional structural information. Despite the conceptual advantage of top-down
Laura Gámez-Díaz et al.
Immunology and cell biology, 95(9), 789-802 (2017-06-28)
Biallelic mutations in the human lipopolysaccharide responsive beige-like anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the phenotypic heterogeneity in
William H Fissell et al.
Journal of membrane science, 326(1), 58-63 (2010-01-08)
Silicon micromachining provides the precise control of nanoscale features that can be fundamentally enabling for miniaturized, implantable medical devices. Concerns have been raised regarding blood biocompatibility of silicon-based materials and their application to hemodialysis and hemofiltration. A high-performance ultrathin hemofiltration
Evaluation of endothelin-converting enzyme inhibitors using cultured cells.
Roger Corder
Methods in molecular biology (Clifton, N.J.), 206, 147-164 (2002-08-03)
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