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F4383

Sigma-Aldrich

7-氟苯并呋喃-4-磺酸 铵盐

≥98%

别名:

4-氟-7-磺酸苯并呋咱 铵盐, 7-氟苯呋咱-4-硫酸铵盐, 7-氟苯并-2,1,3-噁二唑-4-磺酸 铵盐, SBD-F

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About This Item

线性分子式:
C6H3FN2O4S · NH3
CAS号:
84806-27-9
分子量:
235.19
Beilstein:
5199564
MDL编号:
MFCD02682109
UNSPSC代码:
12352106
PubChem化学物质编号:
24894861
NACRES:
NA.32

质量水平

200

方案

≥98%

储存条件

protect from light

荧光

λex 380 nm; λem 515 nm

储存温度

−20°C

SMILES字符串

N.OS(=O)(=O)c1ccc(F)c2nonc12

InChI

1S/C6H3FN2O4S.H3N/c7-3-1-2-4(14(10,11)12)6-5(3)8-13-9-6;/h1-2H,(H,10,11,12);1H3

InChI key

JXLHNMVSKXFWAO-UHFFFAOYSA-N

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一般描述

7-氟苯呋嗪-4-磺酸铵盐，又称SBD-F，是一种低分子量敏感荧光探针。SBD-F与巯基发射反应（二硫化物不与SBD-F反应，必须首先还原为硫醇，如三丁基膦），产生高荧光化合物。 硫醇与SBD-F的反应速率随pH升高而逐渐增加。在pH值2-12时观察到高荧光强度。 SBD-F的激发范围为380-385nm，发射范围为510-515nm。

应用

SBD-F适用于皮摩尔级别生物硫醇的HPLC测定。SBD-F已用于通过HPLC方法测量总血浆和血清同型半胱氨酸水平。它也适用于通过串联柱高效液相色谱法和等溶剂体系测定金属硫蛋白。 SBD-F已用于确定蛋白质中半胱氨酸残基二硫键的位置以及检测含半胱氨酸的多肽。
硫醇的荧光探针，HPLC 中生物硫醇的柱前标记物

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000345448
0000337290
0000337290
0000345448
SLCQ9774

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P E Cornwell et al.
Journal of chromatography, 617(1), 136-139 (1993-07-23)
A modification of a previously published method for analysis of total homocysteine in human serum is presented. The modification was implemented to allow use of a different derivatizing agent (i.e., 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonamide) which reacts much faster than the original derivatizing reagent
J B Ubbink et al.
Clinical chemistry, 45(5), 670-675 (1999-05-01)
Various methods are available to measure plasma total homocyst(e)ine (tHcy) concentrations, but whether plasma tHcy assays may be used interchangeably is not known. Results from three different methods [HPLC with fluorescence detection, enzyme immunoassay (EIA), and fluorescence polarization immunoassay (FPIA)]
I Fermo et al.
Journal of chromatography. B, Biomedical sciences and applications, 719(1-2), 31-36 (1998-12-30)
We have modified a high-performance liquid chromatographic (HPLC) procedure based on SBD-F (ammonium-7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate) pre-column derivatization to obtain an assay that is useful for routine clinical total plasma homocysteine (tHcy) analysis. The introduction of easily handled sodium borohydride instead of the
T Toyo'oka et al.
Biomedical chromatography : BMC, 3(4), 166-172 (1989-07-01)
Biological thiols and disulfides in rat and hamster tissues were simultaneously determined by HPLC-fluorescence detection using 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABD-F) and ammonium 7-fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F). The coefficients of variation (CV) of the method for reduced glutathione (GSH) and oxidized glutathione (GSSG) in liver
B L Ling et al.
Journal of pharmaceutical and biomedical analysis, 10(10-12), 985-988 (1992-10-01)
The present investigation analyses the potentials of capillary chromatography using packed fused silica capillaries filled with 5 microns RP-18 for the fluorescence determination of glutathione in human blood samples. Adaptation of conventional HPLC equipment for miniaturized chromatographic assays proved successful.
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