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安全信息

G4251

Sigma-Aldrich

L -还原型谷胱甘肽

≥98.0%

别名:

谷胱甘肽-SH, γ-L-谷酰基-L-半胱氨酰-甘氨酸, GSH

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About This Item

线性分子式:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
CAS号:
70-18-8
分子量:
307.32
Beilstein:
1729812
EC 号:
200-725-4
MDL编号:
MFCD00065939
UNSPSC代码:
12352209
PubChem化学物质编号:
24895164
NACRES:
NA.26

product name

L -还原型谷胱甘肽, ≥98.0%

质量水平

300

检测方案

≥98.0%

形式

powder

颜色

white

mp

192-195 °C (dec.) (lit.)

溶解性

water: 50 mg/mL, clear, colorless

应用

detection

官能团

amine
carboxylic acid
thiol

储存温度

2-8°C

SMILES字符串

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

InChI

1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChI key

RWSXRVCMGQZWBV-WDSKDSINSA-N

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相关类别

Amino Acid Sequence

γ-Glu-Cys-Gly

一般描述

谷胱甘肽（GSH）是一种普遍存在于多种细胞和组织中的分子。GSH中存在的三种氨基酸是甘氨酸、半胱氨酸和谷氨酸。

应用

还原的L-谷胱甘肽（GSH）已用于洗脱缓冲液用于通过使用谷胱甘肽-琼脂糖微珠进行GST（谷胱甘肽S-转移酶）融合蛋白的洗脱。它已用于绘制GSH分析物的标准曲线。
可在5-10 mM下用于从谷胱甘肽琼脂糖洗脱谷胱甘肽S-转移酶(GST)。

生化/生理作用

谷胱甘肽（GSH）可与各种代谢产物和外源性物质形成偶联物。它是各种酶的重要辅助因子。谷胱甘肽参与许多代谢和信号传导通路。谷胱甘肽是硫氧还蛋白和金属硫蛋白等细胞蛋白的硫醇缓冲液。GSH还参与生育酚和抗坏血酸等抗氧化剂的再生。
作为内源性抗氧化剂在减少细胞代谢和呼吸爆发期间生成的活性氧方面发挥重要作用。 谷胱苷肽S-转移酶催化异生素、白三烯和其他亲电子分子生成谷胱苷肽硫醚。 谷胱苷肽也和蛋白质半胱氨酸残基形成二硫键。 经由这些机制，它会产生降低抗癌药功效的逆反效应(paradoxical effect)。

其他说明

如需了解生化试剂系列的更多信息，请填写此表。

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品

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分析证书(COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How do I solubilize Product G4251, L-Glutathione reduced?

    Reduced glutathione is freely soluble in water, dilute alcohol, liquid ammonia, and DMF.

  6. What is the solution stability of Product G4251, L-Glutathione reduced?

    Aqueous solutions readily oxidize in air to oxidized glutathione, GSSG.  Half-lives of reduced glutathione in solution at various pHs and temperatures have been reported.  The half-life of reduced glutathione is increased in the presence of a chelating agent.  For supporting references, please consult the product information sheet (under Documents, above).

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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