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Merck
CN

F0537

Sigma-Aldrich

壳梭孢菌素 来源于扁桃壳梭菌

≥85% (HPLC)

别名:

Fusicoccin A

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About This Item

经验公式(希尔记法):
C36H56O12
CAS号:
分子量:
680.82
MDL编号:
UNSPSC代码:
12352201
PubChem化学物质编号:
NACRES:
NA.25

生物来源

plant (Fusicoccum amygdali)

质量水平

方案

≥85% (HPLC)

表单

solid

储存温度

−20°C

SMILES字符串

COCC1CCC2C(C)C(O)C(OC3OC(COC(C)(C)C=C)C(O)C(OC(C)=O)C3O)C4=C(CC(O)C4(C)C=C12)C(C)COC(C)=O

InChI

1S/C36H56O12/c1-10-35(6,7)45-17-26-30(41)33(46-21(5)38)31(42)34(47-26)48-32-28-24(18(2)15-44-20(4)37)13-27(39)36(28,8)14-25-22(16-43-9)11-12-23(25)19(3)29(32)40/h10,14,18-19,22-23,26-27,29-34,39-42H,1,11-13,15-17H2,2-9H3/b25-14-

InChI key

KXTYBXCEQOANSX-QFEZKATASA-N

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应用

壳梭孢菌素(壳梭孢菌素A)是一种二萜葡萄糖苷植物毒素,用于研究14-3-3-依赖性过程,例如植物和其他具有模式III结合基序的客户蛋白中H+-ATPase的激活。壳梭孢菌素是过氧化氢酶抑制剂的诱导剂,可导致植物氧化损伤。

其他说明

一种对植物具有多种生理效应的二萜糖苷。
为了全面了解我们针对客户研究提供的各种单糖产品,建议您访问我们的碳水化合物分类页面。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions.
Rolf Rose et al.
Angewandte Chemie (International ed. in English), 49(24), 4129-4132 (2010-05-04)
A H de Boer
Biochemical Society transactions, 30(4), 416-421 (2002-08-28)
Turgor pressure is a cellular parameter, important for a range of physiological processes in plants, like cell elongation, gas exchange and gravitropic/phototropic bending. Regulation of turgor pressure involves ion and water transport at the expense of metabolic energy (ATP). The
Michiko Takahashi et al.
Angewandte Chemie (International ed. in English), 51(2), 509-512 (2011-11-23)
Fluorescent combination: Cell-penetrating probes derived from the diterpene fusicoccin can form ternary complexes with 14-3-3 proteins and phosphopeptide ligands, whereupon the probes site-specifically attach a fluorescent tag onto the surface of the 14-3-3 proteins.
Koshi Kawakami et al.
Anti-cancer agents in medicinal chemistry, 12(7), 791-800 (2012-01-24)
Malignant cells in solid tumors survive under prolonged hypoxia and can be a source of resistance to current cancer therapies. Tumor hypoxia is also associated with a more malignant phenotype and poor survival in cancer patients. Recent progress in our
Christian Ottmann et al.
Molecular cell, 25(3), 427-440 (2007-02-10)
Regulatory 14-3-3 proteins activate the plant plasma membrane H(+)-ATPase by binding to its C-terminal autoinhibitory domain. This interaction requires phosphorylation of a C-terminal, mode III, recognition motif as well as an adjacent span of approximately 50 amino acids. Here we

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