质量水平
检测方案
≥98% (TLC)
形式
powder
颜色
white to off-white
溶解性
H2O: soluble
ethanol: soluble
创始人
Bristol-Myers Squibb
储存温度
2-8°C
SMILES字符串
Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI
1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key
KFYRPLNVJVHZGT-UHFFFAOYSA-N
基因信息
human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , SLC6A2(6530) , SLC6A4(6532)
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应用
盐酸阿密曲替林已用于：
- 研究其作为抗抑郁药对酸性鞘磷脂酶转基因(t-ASM)小鼠社会行为和记忆的影响
- 分析其作为三环类抗抑郁药物对人全血中糖皮质受体功能的影响
- 研究其作为抗抑郁药对氯喹诱导小鼠搔抓和运动行为的影响
生化/生理作用
三环类抗抑郁药；抑制去甲肾上腺素和5-羟色胺转运蛋白，Kis分别为100 nM和14.7 nM；对α1-肾上腺素能受体，5-羟色胺和毒蕈碱乙酰胆碱受体具有高体外亲和力。
盐酸阿密曲替林(Amitriptyline)可用于治疗焦虑、躁郁和更年期抑郁症。它具有抗组胺、抗胆碱和抗血清素特性。盐酸阿密曲替林是两亲性药物，具有神经抑制活性。
特点和优势
粉末的保质期至少为三年。
相关产品
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Nadine Beckmann et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(4), 1460-1471 (2017-10-17)
Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities. We investigated arthritis severity by measuring joint swelling
Neha Maurya et al.
Journal of biomolecular structure & dynamics, 35(6), 1367-1380 (2016-05-05)
Herein, we have explored the interaction between amitriptyline hydrochloride (AMT) and hemoglobin (Hb), using steady-state and time-resolved fluorescence spectroscopy, UV-visible spectroscopy, and circular dichroism spectroscopy, in combination with molecular docking and molecular dynamic (MD) simulation methods. The steady-state fluorescence reveals
Iulia Zoicas et al.
PloS one, 11(9), e0162498-e0162498 (2016-09-07)
Major depressive disorder is often associated with deficits in social and cognitive functioning. Mice transgenic for acid sphingomyelinase (t-ASM) were previously shown to have a depressive-like phenotype, which could be normalized by antidepressant treatment. Here, we investigated whether t-ASM mice
L A Carvalho et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 20(6), 379-387 (2010-03-17)
Clinical studies have demonstrated an impairment of glucocorticoid receptor (GR)-mediated negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis in patients with major depression (GR resistance), and its resolution by antidepressant treatment. Recently, we showed that this impairment is indeed due to
Gema Tarrasón et al.
Experimental dermatology, 26(11), 1105-1111 (2017-06-13)
Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available. Animal models replicating the pathophysiology of pruritus are needed to support the development of new drugs. Induction of pruritus by chloroquine (CQ) in mice is
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