B9934
BTA-1
≥98% (HPLC), solid
别名:
2-（4′-甲胺苯基）苯并噻唑
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关于此项目
经验公式（希尔记法）:
C14H12N2S
化学文摘社编号:
分子量:
240.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
BTA-1, ≥98% (HPLC), solid
InChI
1S/C14H12N2S/c1-15-11-8-6-10(7-9-11)14-16-12-4-2-3-5-13(12)17-14/h2-9,15H,1H3
SMILES string
CNc1ccc(cc1)-c2nc3ccccc3s2
InChI key
FHJRKGXJBXPBGA-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: soluble ~10 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... APP(351)
Biochem/physiol Actions
BTA-1 是 β 的探针-淀粉样蛋白聚集体；荧光硫黄素-T 衍生物；对淀粉样沉积物表现出高亲和力；显示比硫黄素-T 高 50 倍的亲和力；选择性染色 PS1/APP 转基因小鼠大脑中的脑斑块和脑血管淀粉样沉积物，以及 aβAD 患者死后脑组织中的原纤维；穿过血脑屏障。
BTA-1 是一种荧光硫黄素-T 衍生物，对 β 亲和力高 50 倍-淀粉样蛋白聚集体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Chester A Mathis et al.
Bioorganic & medicinal chemistry letters, 12(3), 295-298 (2002-01-30)
The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the
Alex C Kwan et al.
Optics express, 17(5), 3679-3689 (2009-03-05)
Intrinsic optical emissions, such as autofluorescence and second harmonic generation (SHG), are potentially useful for functional fluorescence imaging and biomedical disease diagnosis for neurodegenerative diseases such as Alzheimer's disease (AD). Here, using multiphoton and SHG microscopy, we identified sources of
Ruiqing Ni et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(6), 960-966 (2018-02-09)
Fibrillary tau aggregates in Alzheimer disease and allied neurodegenerative disorders have been visualized in vivo by PET, whereas mechanistic links between PET-detectable tau deposits and neurotoxicity remain elusive. Here, we took advantage of transgenic mouse models of tauopathies to evaluate
W E Klunk et al.
Life sciences, 69(13), 1471-1484 (2001-09-14)
In vivo assessment of the beta-sheet proteins deposited in amyloid plaques (A beta peptide) or neurofibrillary tangles (tau protein) presents a target for the development of biological markers for Alzheimer's disease (AD). In an effort to develop in vivo beta-sheet
William E Klunk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(6), 2086-2092 (2003-03-27)
2-(4'-methylaminophenyl)benzothiazole (BTA-1) is an uncharged derivative of thioflavin-T that has high affinity for Abeta fibrils and shows very good brain entry and clearance. In this study, we asked whether BTA-1, at concentrations typical of those achieved during positron emission tomography
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