产品名称
硫黄素S, practical grade
等级
practical grade
质量水平
表单
powder
技术
microbe id | staining: suitable
颜色
light beige to dark beige, to Dark Brown
溶解性
ethanol: water (1:1): 1 mg/mL
λmax
360-380
应用
diagnostic assay manufacturing
hematology
histology
储存温度
room temp
SMILES字符串
S1c2c(ccc(c2)C)N(C1=C3C=CC(=[N+](C)C)C=C3)C.[Cl-]
InChI
1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
InChI key
JADVWWSKYZXRGX-UHFFFAOYSA-M
一般描述
硫黄素S有助于对阿尔茨海默′病中的β-淀粉样斑块进行染色和可视化。硫磺素S可与纤维状β-淀粉样斑块结合， 并且不会在斑块中发生扩散。硫磺素-S染色有助于在整个新皮质、海马和丘脑区域中显现较小的斑块。
应用
硫黄素S已用于对组织切片中的β-淀粉样蛋白结构进行染色和可视化。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Attenuation of beta-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity
Yuan P and Grutzendler J
The Journal of Neuroscience, 36(2), 632-641 (2016)
Disha Shah et al.
PloS one, 8(12), e84241-e84241 (2013-12-21)
Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer's disease (AD). AD is a complex disorder, characterised by several pathological features. The problem with FC studies in patients is that it
MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice
Meadowcroft MD, et al.
Journal of Magnetic Resonance Imaging : JMRI, 29(5), 997-1007 (2009)
Genetic modulation of soluble A beta rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease
Fowler SW, et al.
The Journal of Neuroscience, 34(23), 7871-7885 (2014)
Mu Zhang et al.
Theranostics, 8(15), 4262-4278 (2018-08-22)
Rationale: It has been reported that peroxisome proliferator activated receptor γ (PPARγ) level decreases significantly in the brains of Alzheimer's disease (AD) patients and mice models, while the mechanism is unclear. This study aims to unravel the mechanism that amyloid
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