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主要文件

安全信息

A8556

Sigma-Aldrich

6′-唾液酸乳糖 钠盐

from bovine milk or colostrum, ≥97% (HPLC)

别名:

α-NeuNAc-(2→6)-β-D-Gal-(1→4)-D-Glc, 6′-N-乙酰神经氨酸-乳糖 钠盐, 6′-SL

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About This Item

线性分子式:
C23H38NO19Na
CAS号:
35890-39-2
分子量:
655.53
UNSPSC代码:
12352201
NACRES:
NA.25

生物来源

bovine milk or colostrum

质量水平

200

方案

≥97% (HPLC)

表单

powder

杂质

≤1% free N-Acetyl Neuraminic Acid
≤11% water (Karl Fischer)

颜色

white to off-white

溶解性

water: 20 mg/mL, clear, colorless

痕量阳离子

Na: 2.6-4.5% (anhydrous)

储存温度

−20°C

SMILES字符串

[Na+].[H][C@]1(O[C@](C[C@H](O)[C@H]1NC(C)=O)(OC[C@H]2OC(O)[C@H](O)[C@@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)C([O-])=O)[C@H](O)[C@H](O)CO

InChI

1S/C23H39NO19.Na/c1-6(27)24-11-7(28)2-23(22(37)38,43-19(11)12(30)8(29)3-25)39-5-10-18(15(33)16(34)20(36)40-10)42-21-17(35)14(32)13(31)9(4-26)41-21;/h7-21,25-26,28-36H,2-5H2,1H3,(H,24,27)(H,37,38);/q;+1/p-1/t7-,8+,9+,10+,11+,12+,13-,14-,15+,16+,17+,18+,19+

InChI key

FLXUDTRTHITHST-UHWLIUQISA-M

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应用

6'-唾液酸乳糖是一种化合物，其中乙酰神经氨酸 (NANA) 单元在 6 位与乳糖的半乳糖基单元连接。在 3'-唾液酸乳糖中，该连接位于 3 位。3'-唾液酸乳糖和 6′-唾液酸乳糖用于区分和表征病毒的结合域，如流感病毒和鼻炎病毒，它们识别 NANA 封端细胞表面受体。3'-唾液酸乳糖和 6'-唾液酸乳糖用作分析方法中的引用化合物，用于测定乳汁和初乳等物质中是否存在唾液酸乳糖。

其他说明

为了全面了解我们针对客户研究提供的各种寡糖产品，建议您访问我们的碳水化合物分类页面。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
0000362291
0000319015
0000309216
0000309216
0000319015

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Maria Elena Ortiz-Soto et al.
PloS one, 11(5), e0155410-e0155410 (2016-05-12)
Sialyltransferases (STs) are disulfide-containing, type II transmembrane glycoproteins that catalyze the transfer of sialic acid to proteins and lipids and participate in the synthesis of the core structure oligosaccharides of human milk. Sialic acids are found at the outermost position
Rit Bahadur Gurung et al.
Regulatory toxicology and pharmacology : RTP, 95, 182-189 (2018-03-21)
We performed a series of toxicity studies on the safety of 6'-sialyllactose (6'-SL) sodium salt as a food ingredient. 6'-SL sodium salt, up to a maximum dose of 5000 μg/plate, did not increase the number of revertant colonies in five
Ousman Jobe et al.
Journal of leukocyte biology, 99(6), 1089-1106 (2015-12-17)
Monocytes and monocyte-derived macrophages express relatively low levels of CD4. Despite this, macrophages can be effectively infected with human immunodeficiency virus type 1. Macrophages have a critical role in human immunodeficiency virus type 1 transmission; however, the mechanism or mechanisms
Shuang-Xi Chen et al.
Neural regeneration research, 15(6), 1058-1065 (2019-12-12)
Oxidative stress contributes to the pathogenesis of neurodegenerative diseases. With the aim to find reagents that reduce oxidative stress, a phage display library was screened for peptides mimicking α2,6-sialyllactose (6'-SL), which is known to beneficially influence neural functions. Using Sambucus
Randall C Robinson et al.
PloS one, 13(4), e0196513-e0196513 (2018-04-27)
Milk oligosaccharides (OS) are a key factor that influences the infant gut microbial composition, and their importance in promoting healthy infant development and disease prevention is becoming increasingly apparent. Investigating the structures, properties, and sources of these compounds requires a
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