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Merck
CN
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文件

安全信息

A8681

Sigma-Aldrich

3′-唾液酸乳糖

from bovine milk or colostrum, ≥97% (HPLC)

别名:

α-NeuNAc-(2→3)-β-D-Gal-(1→4)-D-Glc, 3′-SL, 3′-唾液酸-D-乳糖, 3&8242-N-乙酰神经氨酸乙酯-D-乳糖 钠盐, NANA-乳糖

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About This Item

经验公式（希尔记法）:
C23H39NO19
CAS号:
35890-38-1
分子量:
633.55
Beilstein:
75357
MDL编号:
MFCD00166999
UNSPSC代码:
12352201
PubChem化学物质编号:
24891358
NACRES:
NA.25

生物来源

bovine milk or colostrum

质量水平

200

检测方案

≥97% (HPLC)

形式

powder

颜色

white

溶解性

water: 20 mg/mL, clear, colorless

痕量阳离子

Na: 3.1-4.7%

储存温度

−20°C

SMILES字符串

[Na+].[H]C(=O)[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@]2(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O2)[C@H](O)[C@H](O)CO)C([O-])=O)[C@H]1O)[C@H](O)CO

InChI

1S/C23H39NO19.Na/c1-7(29)24-13-8(30)2-23(22(38)39,42-19(13)15(35)10(32)4-26)43-20-16(36)12(6-28)40-21(17(20)37)41-18(11(33)5-27)14(34)9(31)3-25;/h3,8-21,26-28,30-37H,2,4-6H2,1H3,(H,24,29)(H,38,39);/q;+1/p-1/t8-,9-,10+,11+,12+,13+,14+,15+,16-,17+,18+,19+,20-,21-,23-;/m0./s1

InChI key

LTWFUJWFLMHANB-TZCPRLTCSA-M

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相关类别

应用

3′-唾液乳糖是一种化合物，在乙酰神经氨酰（NANA）单元中，在 3 号位连接乳糖的半乳糖单元。在 6′-唾液乳糖中，在 6 号位产生这种连接。3′-唾液酸乳糖和 6′-唾液酸乳糖用于区分和表征病毒（如流感病毒和鼻炎病毒）的结合域，它们能识别 NANA 覆盖的细胞表面受体。3′-唾液乳糖和 6′-唾液乳糖用作测量其在牛奶和初乳等材料中的含量的分析方法中的参考化合物。

其他说明

为了全面了解我们针对客户研究提供的各种寡糖产品，建议您访问我们的碳水化合物分类页面。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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J C Wilson et al.
Bioorganic & medicinal chemistry letters, 10(24), 2791-2794 (2001-01-02)
1H NMR spectroscopy has been used to investigate the transfer of sialic acid from sialic acid donor molecules to acceptor molecules using the trans-sialidase from Typanosoma cruzi. It is clearly demonstrated that NMR spectroscopy is an efficient and powerful means
Nuria Izquierdo-Useros et al.
PLoS biology, 10(4), e1001315-e1001315 (2012-05-01)
HIV-1 is internalized into mature dendritic cells (mDCs) via an as yet undefined mechanism with subsequent transfer of stored, infectious virus to CD4+ T lymphocytes. Thus, HIV-1 subverts a DC antigen capture mechanism to promote viral spread. Here, we show
S Swaminathan et al.
Nature structural biology, 7(8), 693-699 (2000-08-10)
Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A resolution, respectively, provide insight into its
J V Mysore et al.
Gastroenterology, 117(6), 1316-1325 (1999-12-02)
Helicobacter pylori can be eradicated by administration of antimicrobials, but resistant strains have emerged, and there is a need for novel therapeutic approaches against this infection. This study aimed to determine the safety and efficacy of 3'-sialyllactose sodium salt (3'SL)
Maarten H Wilbrink et al.
Journal of agricultural and food chemistry, 63(25), 5976-5984 (2015-06-06)
Decoration of prebiotic galacto-oligosaccharides (GOS) with sialic acid yields mixtures of GOS and sialylated GOS (Sia-GOS), novel products that are expected to have both prebiotic and antiadhesive functionalities. The recombinantly produced trans-sialidase enzyme from Trypanosoma cruzi (TcTS), an enzyme with
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