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69554

Sigma-Aldrich

肽聚糖 来源于枯草芽孢杆菌

别名:

PGN

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About This Item

MDL编号:
MFCD00212486
UNSPSC代码:
41116134
NACRES:
NA.21

一般描述

肽聚糖。是一种生物聚合物，是革兰氏阳性菌细胞壁的主要成分。肽聚糖由 N -乙酰基葡糖胺和 N -乙酰基胞壁酸交替单位的碳水化合物骨架组成，并被 D -和 L -氨基酸修饰。 N -乙酰胞壁酸残基与寡肽交联。末端肽为 D -丙氨酸，但其他氨基酸以 D -异构体存在。

应用

肽聚糖可用于裂解酶（如裂解酶）的活性评估。建议使用浓度为 0.15-3μ 的肽聚糖g/ml，溶于水或缓冲液，在 450 nm 处测定。肽聚糖不溶解，但在水中产生混悬液。
肽聚糖可激活 Toll 样受体 2 (TLR2)，TLR2 存在于哺乳动物细胞中以刺激淋巴细胞。也可作为 Poly (I:C) 的拮抗剂发挥作用。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000322617
0000322617
0000256007
0000256007
0000137174

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is Product 69554, Peptidoglycan, Gram positive or Gram negative?

    Peptidoglycan is Gram positive.

  6. What is the method of preparation of Product 69554, Peptidoglycan?

    Peptidoglycan is made by fermentation and so it is from vegetative cell bacteria.  Peptidoglycan is from strain DSM 10.

  7. What is the molecular weight of Product 69554, Peptidoglycan?

    Unfortunately, we have no references reporting the molecular weight of peptidoglycan.  Because it is not soluble without destroying the original structure, the molecular weight can not be determined by suitable analytical methods (GPC, viscosity, light scattering).

  8. What is the solubility of Product 69554, Peptidoglycan?

    Peptidoglycans are insoluble in all solvents.  To increase the recovery of solubility, let the peptidoglycan soak in an aqueous buffer for several hours or overnight.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Angela Cuttitta et al.
Fish & shellfish immunology, 67, 86-94 (2017-06-06)
Gene family encoding allograft inflammatory factor-1 (AIF-1) is well conserved among organisms; however, there is limited knowledge in lower organisms. In this study, the first AIF-1 homologue from cnidarians was identified and characterised in the sea anemone Anemonia viridis. The
Christian Stelter et al.
PloS one, 6(6), e20749-e20749 (2011-06-23)
Intestinal inflammation induces alterations of the gut microbiota and promotes overgrowth of the enteric pathogen Salmonella enterica by largely unknown mechanisms. Here, we identified a host factor involved in this process. Specifically, the C-type lectin RegIIIβ is strongly upregulated during
Qian Zhu et al.
Fish & shellfish immunology, 100, 9-17 (2020-03-05)
Interleukin (IL)-11 is a multifunctional cytokine that exerts a series of important immunomodulatory effects and exists in many tissues and cells. A 1106-bp nucleotide sequence representing the complete cDNA of IL-11 was obtained from large yellow croaker (Larimichthys crocea), containing
Yichao Xie et al.
Fish & shellfish immunology, 106, 384-392 (2020-08-11)
Antimicrobial peptide (AMP) is a crucial component of the innate immune system in crustaceans. In mud crab, Scylla paramamosain, a commercially important species, a glycine-rich antimicrobial peptide (Spgly-AMP) gene was newly identified and putatively encoded a 26aa signal peptide and
Isa Santos et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(22), 12281-12287 (2020-05-20)
Sepsis is a life-threatening organ dysfunction condition caused by a dysregulated host response to an infection. Here we report that the circulating levels of growth and differentiation factor-15 (GDF15) are strongly increased in septic shock patients and correlate with mortality.
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商品

肽聚糖的结构、生物合成和功能

肽聚糖（PGN）的基本结构含有N-乙酰葡糖胺（GlcNAc）与N-乙酰胞壁酸交替单元的碳水化合物主链，其中N-乙酰胞壁酸残基与肽交联。

Peptidoglycan Structure and Biosynthesis

Peptidoglycan structure: alternating GlcNAc and N-acetylmuramic acid cross-linked to peptides form the basic backbone.

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