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77140

Sigma-Aldrich

肽聚糖 来源于金黄色葡萄球菌

cell wall component

别名:

Peptidoglycan from S. aureus

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About This Item

MDL编号:
MFCD00212486
UNSPSC代码:
12352201
NACRES:
NA.32

质量水平

100

表单

lyophilized powder

溶解性

soluble, hazy to turbid, colorless to faintly yellow

储存温度

−20°C

相关类别

应用

金黄色葡萄球菌来源肽聚糖用于：
  • 刺激淋巴细胞：肽聚糖激活Toll样受体2 (TLR2)，存在于哺乳动物细胞中。它作为聚肌胞的拮抗剂
  • 用于通过腹腔接种至单独样本刺激g型溶菌酶
  • 用在磷酸盐缓冲液中并注射到露斯塔野鲮鱼中，进而研究其对核苷酸结合的寡聚化结构域-2 (NOD-2)基因表达的影响

生化/生理作用

革兰氏阳性细菌的细胞壁主要由肽聚糖组成。它由肽桥互相连接的多糖链组成。这种肽聚糖使细胞壁具有一定的刚性，并使细胞具有机械强度。它是一种表面分子，能够刺激免疫反应，包括导致发热的细胞因子。

包装

无底玻璃瓶。内容物在插入式融锥内。

其他说明

革兰氏阳性菌细胞壁的主要成分。由N-乙酰-D-葡糖胺和胞壁酸残基以β 1-4糖苷键交替相连形成的聚糖骨架组成。细菌肽聚糖的免疫活性；细菌细胞壁的肽聚糖类型及其分类学意义；在葡萄球菌感染期间对肽聚糖的抗体反应。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCJ7175
BCCF2500
BCCC1420
BCBZ7206
BCBW7713

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Can Product 77140, Peptidoglycan, be solubilized in water?

    No, the product is not soluble in water, or in other solvents for that matter. It forms a suspension in water.  

  6. Does Product 77140, Peptidoglycan, have a recommended retest date?

    If a product has a recommended retest date this would be on the Certificate of Analysis found at our website. If no recommended retest date is found on the Certificate of Analysis, then the guarantee of quality is one year from the time of delivery for unopened bottles stored at the recommended temperature.

  7. How can solutions of Product 77140, Peptidoglycan, be stored?

    Sigma has not evaluated the solution stability of solutions.  It is therefore recommended that fresh solutions be prepared.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Xue Kong et al.
Frontiers in physiology, 9, 1476-1476 (2018-11-09)
Vesicomyidae clams are common species living in cold seeps, which incorporates symbiotic bacteria into their body maintaining endosymbiosis relationship. As members of pattern recognition receptor (PRR) family, peptidoglycan recognition proteins (PGRPs) recognize pathogen associated molecular patterns and play an important
L J Wheat et al.
The Journal of infectious diseases, 147(1), 16-22 (1983-01-01)
Levels of antibodies to peptidoglycan were measured by solid-phase radioimmunoassay in 76 patients with Staphylococcus aureus infections and 44 patients with infections caused by other bacteria. Levels of IgM antibodies to peptidoglycan were elevated in 24% of the patients with
The immunological activities of bacterial peptidoglycans.
D E Stewart-Tull
Annual review of microbiology, 34, 311-340 (1980-01-01)
Genomic characterization, phylogeny and gene regulation of g-type lysozyme in sole (Solea senegalensis)
Ponce M, et al.
Fish & Shellfish Immunology, 31(6), 925-937 (2011)
A peptidoglycan recognition protein in innate immunity conserved from insects to humans
Kang D, et al.
Proceedings of the National Academy of Sciences of the USA, 95(17), 10078-10082 (1998)
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商品

肽聚糖的结构、生物合成和功能

肽聚糖（PGN）的基本结构含有N-乙酰葡糖胺（GlcNAc）与N-乙酰胞壁酸交替单元的碳水化合物主链，其中N-乙酰胞壁酸残基与肽交联。

Peptidoglycan Structure and Biosynthesis

Peptidoglycan structure: alternating GlcNAc and N-acetylmuramic acid cross-linked to peptides form the basic backbone.

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