生物来源
Staphylococcus aureus
质量水平
形式
lyophilized powder
官能团
phospholipid
脂质类型
polymerizable lipids
运输
ambient
储存温度
2-8°C
一般描述
脂磷壁酸（LTA）是一种与脂质共价结合的磷酸二酯连接的甘油磷酸酯的线性聚合物。磷酸甘油上的 C2 位置通常是糖基化或 D-丙氨酰化。LTA 是两亲性的，这是因为它具有磷酸甘油带负电荷的主链和疏水性脂质。脂质部分疏水性地结合到细胞膜上，而聚甘油磷酸部分则延伸到细胞壁中。
脂磷壁酸（LTA）是附着于革兰氏阳性细菌细胞壁上丰富的脂质的磷壁酸。LTA 是由 Toll 样受体 2（TLR2）识别的病原体相关分子模式（PAMP），这种识别导致 NF-kB的激活。
应用
金黄色葡萄球菌的脂磷壁酸已用于：
- 采用酶联免疫吸附试验（ELISA）研究辛伐他汀与脂多糖和脂磷壁酸的结合特性
- 通过夹心 ELISA 法测定脾细胞中产生的白细胞介素-6
- 作为 Toll 样受体 2/6（TLR2/6）激动剂，研究其诱导肿瘤杀伤 M1 巨噬细胞表型的潜力
生化/生理作用
脂磷壁酸（LTA）是革兰氏阳性细菌细胞壁的复杂组分，其参与广泛的细胞过程，例如刺激免疫应答和细胞信号传导途径。 脂磷壁酸在革兰氏阳性细菌种类之间存在差异。 来自金黄色葡萄球菌的脂磷壁酸可用于与其他细菌的脂磷壁酸比较其结构、免疫原性和功能。
脂磷壁酸（LTA）是革兰氏阳性菌细胞壁的一种复杂组分，与多种细胞过程有关，例如刺激免疫反应和细胞信号传导途径。脂磷壁酸在革兰氏阳性细菌种类之间存在差异。来自金黄色葡萄球菌的脂磷壁酸可用于与其他细菌的脂磷壁酸比较其结构、免疫原性和功能。
相关产品
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
S Morath et al.
The Journal of experimental medicine, 193(3), 393-397 (2001-02-07)
Lipoteichoic acids (LTAs) have been proposed as putative Gram-positive immunostimulatory counterparts to Gram-negative lipopolysaccharides. However, LTA from Staphylococcus aureus, the clinically most frequent Gram-positive pathogen, was inactive after purification. Here, a novel isolation procedure to prepare pure (>99%) biologically active
Simin Rezania et al.
Cancer cell international, 14, 54-54 (2014-06-27)
Many types of tumors are organized in a hierarchy of heterogeneous cell populations with different molecular signature. Such heterogeneity may be associated with different responsiveness to microenvironment stimuli. In the present study, the effects of lipopolysaccharide (LPS) and lipoteichoic acid
Nien-Tzu Chou et al.
Evidence-based complementary and alternative medicine : eCAM, 2012, 735396-735396 (2013-01-11)
Chlorella sorokiniana (CS) is a unicellular green alga. The extracts of Chlorella have been used as treatments for relieving hypertension and modulating immune response. The detailed mechanisms are not clear yet. In this study, we sought to study the molecular
Etheresia Pretorius et al.
Cardiovascular diabetology, 16(1), 141-141 (2017-11-04)
We have previously shown that many chronic, inflammatory diseases are accompanied, and possibly partly caused or exacerbated, by various coagulopathies, manifested as anomalous clots in the form of 'dense matted deposits'. More recently, we have shown that these clots can
Varenka J Barbero-Becerra et al.
World journal of gastroenterology, 17(10), 1317-1325 (2011-04-02)
To study the role of gram-positive and gram-negative bacteria in the pathogenesis of liver injury, specifically the activation of inflammatory mediators. Peripheral blood mononuclear cells of 20 out-patients were studied, 10 of them with cirrhosis. Peripheral blood mononuclear cells were
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