价格与库存信息目前不能提供
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生物来源
human aorta (normal, tunica intima and tunica media, fibrous plaque-free)
质量水平
包装
pkg of 500,000 cells
制造商/商品名称
Cell Applications, Inc
生长模式
Adherent
核型
2n = 46
形态学
smooth muscle
技术
cell culture | mammalian: suitable
相关疾病
cardiovascular diseases
运输
dry ice
相关类别
1 of 4
此商品 | 35405F | 35005A | 351405A |
|---|---|---|---|
| relevant disease(s) cardiovascular diseases | relevant disease(s) cardiovascular diseases | relevant disease(s) diabetes; stroke; cardiovascular diseases | relevant disease(s) stroke; cardiovascular diseases |
| biological source human aorta (normal, tunica intima and tunica media, fibrous plaque-free) | biological source human aorta (normal, tunica intima and tunica media, fibrous plaque-free) | biological source human coronary artery (normal, tunica intima and media) | biological source human carotid artery (normal) |
| morphology smooth muscle | morphology smooth muscle | morphology smooth muscle | morphology - |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| karyotype 2n = 46 | karyotype 2n = 46 | karyotype 2n = 46 | karyotype 23 |
一般描述
Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details.
Human Aortic Smooth Muscle Cells (HAOSMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.
HAOSMC have been utilized in dozens of research studies, for example, to:elucidate cytokines and growth factors signaling pathways implicated in the molecular regulation of smooth muscle cell proliferation, migration, and overall vascular function (Liu, 2009; Tan, 2009; Seymour, 2010; Chen, 2011; Hirase, 2013; Stein, 2013):
Characterization: Positive for smooth muscle cell specific alpha-actin expression.
Human Aortic Smooth Muscle Cells (HAOSMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.
HAOSMC have been utilized in dozens of research studies, for example, to:elucidate cytokines and growth factors signaling pathways implicated in the molecular regulation of smooth muscle cell proliferation, migration, and overall vascular function (Liu, 2009; Tan, 2009; Seymour, 2010; Chen, 2011; Hirase, 2013; Stein, 2013):
- Understand hyperglycemia-related risk factors for atherosclerosis in diabetes patients (Maier, 2010), as well as effects of ethanol on vascular calcification (Oros, 2012)
- Investigate extracellular elastic matrix deposition and its role in cardiovascular health, repair of damaged vasculature and successful tissue engineering (Gacchina, 2010, 2011; Venkataraman, 2012; Phillippi, 2013)
- Study mechanisms and effects of mechanoregulation on proliferation and function of smooth muscle cells (Jiang, 2009; Venkataraman, 2013, 2014), and develop advanced stent technology, including novel surface materials, and drug and gene delivery systems to prevent restenosis and other occlusive vasculopathies (Brito, 2010; Deshpande, 2013; Kakade, 2013; Lamichhane, 2013)
Characterization: Positive for smooth muscle cell specific alpha-actin expression.
细胞系来源
Aorta
应用
aortic wall contraction, role of smc under normal conditions, blood pressure, distribution of oxygenated blood through systemic circulation
制备说明
- Can be cultured at least 16 doublings
传代培养常规
Please refer to the HAOSMC Culture Protocol.
免责声明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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Shear stress has been reported to result in various metabolic effects in endothelial cells (ECs), which in turn contribute to the regulation of their vascular functions. Peroxisome proliferator-activated receptors (PPARs) have been reported to regulate lipid metabolism and have been
实验方案
Technical information for working with human aortic smooth muscle cells including thawing, subculturing and cryopreservation.
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