质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
protect from light
颜色
white to beige
mp
208 °C (dec.) (lit.)
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O
InChI
1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+
InChI key
FLOSMHQXBMRNHR-QPJJXVBHSA-N
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生化/生理作用
Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.
Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.
其他说明
Light sensitive
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
WGK
WGK 3
The pharmacology of methazolamide in relation to the treatment of glaucoma.
Maren TH, et al.
Investigative Ophthalmology & Visual Science, 16(8), 730-742 (1977)
Ming-Tao Yang et al.
Psychopharmacology, 232(20), 3763-3772 (2015-08-01)
Dysregulation of noradrenergic and dopaminergic systems is involved in the pathology of attention deficit hyperactivity disorder (ADHD). Carbonic anhydrase (CA) has been reported to affect monoamine transmission in the central nervous system. The aim of this study is to investigate
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